缺血性脑卒中患者糖化血红蛋白与血浆致动脉粥样硬化指数的相关性研究

目的探讨缺血性脑卒中患者糖化血红蛋白(HbAlc)与血浆致动脉粥样硬化指数(AIP)的关系。方法选择2017年1月至2017年6月河北省保定市第一中心医院神经内科收治的缺血性脑卒中患者117例.选择同期在本院体检健康者48例为对照组,采用高压液相方法检测两组研究对象血中HbAlc水平,并计算AIP(等于甘油三酯与高密度脂蛋白胆固醇比值的对数):结果缺血性脑卒中组吸烟史(55.6%vs.35.7%,P=0.027)、高血压病史(76.9%vs.42.8%,P=0.000)、甘油三脂(1.58±0.96vs.1.19±0.87,P=0.028)、基线收缩压(151.62±21.55vs.134.12±16.97,P=0.000)、基线舒张压(91.58±14.16vs.82.00±12.71,P=0.000)sHbAlc(6.8±1.8vs.5.5±0.6,P=0.001)、AIP(0.05±0.26vs.-0.06±0.24,P=0.015)均高于对照组,差异有统计学意义(P<0.05)。缺血性脑卒中组HbAlc与AIP呈正相关(r=0.276,P=0.()03)。结论缺血性脑卒中患者HbA1c与AIP正相关,因此定期检测HbAlc和A1P,积极控制血糖和血脂,对于预防缺血性脑卒中会起到一定的作用。

Correlation between glycosylated hemoglobin and atherogenic index of plasma in patients with ischemic stroke

Objective To investigate the correlation between glycosylated hemoglobin (HbA1c) and atherogenic index of plasma (AIP) in patients with ischemic stroke.Methods A total of 117 patients with ischemic stroke who were admitted to Department of Neurology in Baoding NO.1 Central Hospital from January to June, 2017 were enrolled as ischemic stroke group, and 48 healthy individuals who underwent physical examination in this hospital during the same period of time were enrolled as control group. High-pressure liquid chromatography was used to measure the level of HbA1c in blood, and AIP (equal to the logarithm of the ratio of triglyceride and high-density lipoprotein cholesterol) was calculated.Results Compared with the control group, the ischemic stroke group had a significantly higher proportion of patients with a smoking history (55.6% vs 35.7%, P=0.027) or a medical history of hypertension (76.9% vs 42.8%, P=0.000), as well as significantly higher triglyceride (1.58±0.96 vs 1.19±0.87, P=0.028), baseline systolic blood pressure (151.62±21.55 vs 134.12±16.97, P=0.000), baseline diastolic blood pressure (91.58±14.16 vs 82.00±12.71, P=0.000), HbA1c (6.8±1.8 vs 5.5±0.6, P=0.001), and AIP (0.05±0.26 vs -0.06±0.24, P=0.015). HbA1c was positively correlated with AIP in the ischemic stroke group (r=0.276, P=0.003).Conclusions HbA1c is positively correlated with AIP in patients with ischemic stroke. Therefore, regular measurement of HbA1c and AIP and active control of blood glucose and blood lipids may help to prevent ischemic stroke.