| 细胞因子和神经递质双重监测在乳腺癌患者伴发抑郁症防治中的研究 |
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| 引用本文： | 朱青,王健,杨蕙,孟盼,柳卓.细胞因子和神经递质双重监测在乳腺癌患者伴发抑郁症防治中的研究[J].国际检验医学杂志,2019,40(5):579-581,585. |
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| 作者姓名： | 朱青 王健 杨蕙 孟盼 柳卓 |
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| 作者单位： | 湖南省肿瘤医院/中南大学湘雅医学院附属肿瘤医院药学部 ,湖南长沙 410013;湖南中医药大学/湖南省中药粉体与创新药物省部共建国家重点实验室培育基地 ,湖南长沙 410208;长沙市第三医院药学部 ,湖南长沙,410015;湖南中医药大学第一附属医院中心实验室 ,湖南长沙,410007;湖南中医药大学/湖南省中药粉体与创新药物省部共建国家重点实验室培育基地 ,湖南长沙,410208 |
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| 基金项目： | 湖南省中医药局项目;湖南省教育厅优秀青年项目 |
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| 摘 要： | 目的探讨细胞因子和单胺类神经递质在乳腺癌伴发抑郁患者体内的水平及其对该病临床防治的重要意义。方法对124例乳腺癌住院患者进行抑郁评估,并根据评分结果,将其分为乳腺癌伴抑郁症组71例,乳腺癌不伴抑郁症组53例;同时选取身心健康的女性45例作为对照组。采用酶联免疫吸附试验(ELISA)法检测各组患者血清肿瘤坏死因子-α(TNF-α)和白细胞介素-6(IL-6)、多巴胺(DA)、五羟色胺(5-HT)水平,并分析其与乳腺癌伴发抑郁症的相关性。结果组间比较结果表明,与对照组比较,乳腺癌伴发或不伴发抑郁症组患者血清IL-6、TNF-α均显著升高(P<0.01),但仅乳腺癌伴发抑郁症患者血清DA、5-HT水平显著降低(P<0.01)。与乳腺癌不伴发抑郁症组比较,伴发抑郁症的乳腺癌患者血清IL-6、TNF-α水平显著升高而DA、5-HT水平显著降低(P<0.01)。Pearson分析显示,IL-6、TNF-α与乳腺癌伴发抑郁症呈正相关,而DA、5-HT与乳腺癌伴发抑郁症则呈负相关(P<0.05)。Logistic回归分析显示,TNF-α是乳腺癌伴发抑郁症发生的独立危险因素(P<0.05)。结论细胞因子水平增加和单胺类神经递质水平降低与乳腺癌伴发抑郁症的发生发展密切相关,可作为临床监测的重要参考指标。
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| 关 键 词： | 炎症因子 神经递质 乳腺癌 抑郁症 |
Double monitoring of cytokines and neurotransmitters in the prevention and treatment of depression in breast cancer patients |
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| ZHU Qing,WANG Jian,YANG Hui,MENG Pan,LIU Zhuo.Double monitoring of cytokines and neurotransmitters in the prevention and treatment of depression in breast cancer patients[J].International Journal of Laboratory Medicine,2019,40(5):579-581,585. |
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| Authors: | ZHU Qing WANG Jian YANG Hui MENG Pan LIU Zhuo |
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| Institution: | (Department of Pharmacy,Hu′nan Cancer Hospital/the Affiliated Cancer Hospital of Xiangya School of Medicine,Central South University,Changsha,Hu′nan 410013,China;Hu′nan Key Laboratory of Chinese Materia Media Powder and Innovative Drugs Established by Provincial and Ministry Training Bases/Hunan University of Chinese Medicine,Changsha,Hu′nan 410208,China;Department of Pharmacy,Third Hospital of Changsha,Changsha,Hu′nan 410015,China;Department of Central Laboratory,First Hospital of Hunan University of Traditional Chinese Medicine,Changsha,Hu′nan 410007,China) |
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| Abstract: | ZHU Qing;WANG Jian;YANG Hui;MENG Pan;LIU Zhuo(Department of Pharmacy,Hu′nan Cancer Hospital/the Affiliated Cancer Hospital of Xiangya School of Medicine,Central South University,Changsha,Hu′nan 410013,China;Hu′nan Key Laboratory of Chinese Materia Media Powder and Innovative Drugs Established by Provincial and Ministry Training Bases/Hunan University of Chinese Medicine,Changsha,Hu′nan 410208,China;Department of Pharmacy,Third Hospital of Changsha,Changsha,Hu′nan 410015,China;Department of Central Laboratory,First Hospital of Hunan University of Traditional Chinese Medicine,Changsha,Hu′nan 410007,China) |
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| Keywords: | cytokines neurotransmitters breast cancer depression |
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