| CA125、HE4、β-HCG和AMH联合检测在卵巢癌早期诊断中的应用价值 |
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| 引用本文： | 林丽淑,任溪,陈睿,龙韵洪,王革非.CA125、HE4、β-HCG和AMH联合检测在卵巢癌早期诊断中的应用价值[J].国际检验医学杂志,2019,40(13):1553-1556. |
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| 作者姓名： | 林丽淑 任溪 陈睿 龙韵洪 王革非 |
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| 作者单位： | 汕头大学医学院微生物学与免疫学教研室,广东汕头515041;深圳市福田区第二人民医院检验科,广东深圳518049;深圳市妇幼保健院检验科,广东深圳,518017;深圳市福田区第二人民医院检验科,广东深圳,518049;汕头大学医学院微生物学与免疫学教研室,广东汕头,515041 |
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| 基金项目： | 国家自然科学基金;广东省扬帆计划 |
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| 摘 要： | 目的探讨联合检测糖类抗原125(CA125)、人附睾蛋白4(HE4)、β-人绒毛膜促性腺激素(β-HCG)、人类抗缪勒氏管激素(AMH)在早期诊断卵巢癌中的应用价值。方法选取确诊卵巢癌患者43例为恶性组,良性卵巢肿瘤患者33例为良性组,体检健康女性47例为对照组。用化学发光法检测血清CA125、HE4、β-HCG、AMH水平。并进行统计学分析和诊断性能评价。结果CA125、HE4、AMH3个指标联合检测的受试者工作特征曲线下面积(AUC)为0.95,与CA125、HE4、β-HCG、AMH4个指标联合检测AUC相同,优于传统的CA125、HE4二联检(AUC=0.91)。结论CA125、HE4、AMH联合检测能提高早期卵巢癌的检出率。
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| 关 键 词： | 糖类抗原125 人附睾蛋白4 绒毛膜促性腺激素 抗缪勒氏管激素 卵巢癌 |
Value of combined detection of CA125,HE4,beta-HCG and AMH in early diagnosis of ovarian cancer |
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| LIN Lishu,REN Xi,CHEN Rui,LONG Yunhong,WANG Gefei.Value of combined detection of CA125,HE4,beta-HCG and AMH in early diagnosis of ovarian cancer[J].International Journal of Laboratory Medicine,2019,40(13):1553-1556. |
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| Authors: | LIN Lishu REN Xi CHEN Rui LONG Yunhong WANG Gefei |
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| Institution: | (Department of Microbiology and Immunology,Medical College of Shantou University,Shantou,Guangdong 515041,China;Department of Clinical Laboratory,Second People′s Hospital of Futian District,Shenzhen,Guangdong 518049,China;Department of Clinical Laboratory,Shenzhen Maternal and Child Health Care Hospital,Shenzhen,Guangdong 518017,China) |
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| Abstract: | LIN Lishu;REN Xi;CHEN Rui;LONG Yunhong;WANG Gefei(Department of Microbiology and Immunology,Medical College of Shantou University,Shantou,Guangdong 515041,China;Department of Clinical Laboratory,Second People′s Hospital of Futian District,Shenzhen,Guangdong 518049,China;Department of Clinical Laboratory,Shenzhen Maternal and Child Health Care Hospital,Shenzhen,Guangdong 518017,China) |
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| Keywords: | human antigen 125 human epididymis secretory protein 4 chorionic gonadotropin anti-müllerian hormone ovarian cancer |
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