SRY基因诊断在临床中的应用 |
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引用本文: | 化爱玲,郑梅玲,丁琰. SRY基因诊断在临床中的应用[J]. 实用口腔医学杂志, 1998, 0(4) |
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作者姓名: | 化爱玲 郑梅玲 丁琰 |
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作者单位: | 山西医科大学第一医院 |
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摘 要: | 应用聚合酶链式反应(PCR)扩增技术,对10例染色体核型为46,XY和1例为46,XX/46,XY的性反转、睾丸女性化、两性畸形及男性生殖器发育不良的患者进行了性别决定区(SRY)基因检测。结果表明9例46,XY和1例46,XX/46,XY患者的SRY基因存在,1例46,XY女性患者的SRY基因缺失。该结果表明能够用分子生物学技术对性反转、性发育异常的病因进行分析
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关 键 词: | SRY基因 聚合酶链式反应 性反转 睾丸女性化综合征 男性生殖器发育障碍 |
CLINICAL APPLICATION OF SRY GENE DIAGNOSIS |
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Abstract: | Using PCR amplification technique,we have analysed the SRY gene of eleven patients with sex reversal,testicular feminization,hermaphrodism,male dysgenitalism.The results showed that the SRY gene was deleted in one 46,XY female patient;the other ten patients had normal SRY gene sequence.This results have proved that we could analyse the cause of sex reversal and male dysgenitalism by using molecular biology method. |
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Keywords: | SYR gene polymerase chain reaction sex reversal testicular feminization syndrome male dysgenitalism |
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