Lack of G2019S LRRK2 mutation in a cohort of Taiwanese with sporadic Parkinson's disease. |
| |
Authors: | Hon-Chung Fung Chiung-Mei Chen John Hardy Dena Hernandez Andrew Singleton Yih-Ru Wu |
| |
Affiliation: | Laboratory of Neurogenetics, National Institute on Aging, Bethesda, Maryland, USA. |
| |
Abstract: | Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene have been shown to cause autosomal dominant and sporadic Parkinson's disease (PD). We report here the frequency of a common heterozygous mutation, 2877510G>A, which produces a glycine-to-serine amino acid substitution at codon 2019 in idiopathic Taiwanese PD. The extreme rarity of the G2019S mutation in our population suggests the occurrence of this mutation resulted from a common European founder. |
| |
Keywords: | LRRK2 Parkinson's disease Taiwan mutation |
|
|