| 109例慢性B淋巴系白血病免疫表型特征分析 |
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| 作者姓名： | Wang AQ Geng MJ Zhu MQ Chen L |
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| 作者单位： | 1. 苏州大学医学部实验中心,江苏苏州,215123
2. 苏州大学附属第一医院江苏省血液研究所,江苏苏州,215007 |
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| 摘 要： | 本研究目的在于了解慢性B淋巴系白血病（B-CLL）的免疫表型特征,为临床的诊断、治疗、微小残留病灶检测及预后判断提供依据。应用流式细胞术及一组单克隆抗体,通过双色/三色流式细胞术,采用细胞表面与胞浆联合标记的方法,对109例序贯而来的B-CLL病例进行免疫表型分析。结果表明,109例B-CLL均表达CD19,其他B系抗原CD20、CD22、CD23阳性率分别为95.40%、94.50%、86.20%,无1例表达CD10。在105例B-CLL中有28.60%表达FMC-7,36.20%表达CD38。在所有B-CLL中CD5^＋B-CLL占86.23%,CD5^-B-CLL占13.76%。对50例B-CLL进行ZAP-70的检测,其中12例ZAP-70阳性。在73例B-CLL中,膜表面球蛋白κ轻链阳性多于λ轻链。结论：了解B-CLL的免疫表型特点对此类疾病的诊断及治疗后微小残留病灶的检测具有重要意义,而免疫表型与预后的关系则需作进一步研究。
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| 关 键 词： | 慢性B淋巴系白血病 免疫表型 微小残留病 |
Analysis of immunophenotype characteristics in 109 cases of B lineage chronic B lymphoid leukemia |
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| Wang AQ,Geng MJ,Zhu MQ,Chen L.Analysis of immunophenotype characteristics in 109 cases of B lineage chronic B lymphoid leukemia[J].Journal of Experimental Hematology,2011,19(6):1374-1377. |
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| Authors: | Wang Ai-Qing Geng Mei-Ju Zhu Ming-Qing Chen Li |
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| Institution: | WANG Ai-Qing,GENG Mei-Ju,ZHU Ming-Qing1,CHEN Li1Soochow University Experiment Center,Suzhou 215123,Jiangsu Province,China,1Jiangsu Institute of Hematology,Soochow University First Affiliated Hospital,Suzhou 215007,Chin |
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| Abstract: | This study was aimed to investigate the immunophenotypic characteristics of 109 cases of B-cell chronic lymphoid leukemia(B-CLL) so as to provide evidences for the diagnosis and therapy of B-CLL,and for the detection of the minimal residual disease and its prognosis.Immunophenotyping was performed in 109 patients of B-CLL by two/three color multiparameter flow cytometry analysis using a panel of monoclonal antibodies.The results showed that in 109 cases of B-CLL,all cases expressed CD19,the positive ratios ... |
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| Keywords: | chronic B lymphoid leukemia immunophenotype minimal residual disease |
| 本文献已被 CNKI 维普 万方数据 PubMed 等数据库收录！ |
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