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| 基因芯片筛查外周血中胃癌转移相关基因 | |
| 引用本文： | 黄素英,陈华,田俊,应敏刚,郭福榕,詹文青. 基因芯片筛查外周血中胃癌转移相关基因[J]. 中国实用医药, 2011, 6(30): 1-2 |
| 作者姓名： | 黄素英 陈华 田俊 应敏刚 郭福榕 詹文青 |
| 作者单位： | 1. 福建医科大学公共卫生学院,350004 2. 福建省肿瘤医院 3. 福州市疾病预防控制中心 |
| 基金项目： | 福建省教育厅科技项目，福建医科大学教授基金 |
| 摘 要： | 目的应用基因芯片筛查外周血中胃癌转移相关基因,为探究外周血中胃癌转移分子标志物提供线索。方法采用phalanx人全基因组表达谱芯片检测胃癌发生转移患者与未发生转移患者外周血中基因表达谱差异,利用生物信息学技术分析检测结果。结果从外周血中筛选出胃癌转移相关差异表达基因157个,表达上调基因92个,表达下调基因65个,涉及细胞粘附和运动基因、蛋白水解酶基因等。结论胃癌转移过程涉及多个不同功能基因表达的改变,运用基因芯片技术可初步从外周血中筛选出胃癌转移相关基因。 |
| 关 键 词： | 胃癌 外周血 转移 基因芯片 基因表达谱 |
Screening of metastasis associated genes in peripheral blood of gastric carcer patients by gene chips |
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| HUANG Su-ying,TIAN Jun,YING Min-gang,et al.. Screening of metastasis associated genes in peripheral blood of gastric carcer patients by gene chips[J]. China Practical Medical, 2011, 6(30): 1-2 | |
| Authors: | HUANG Su-ying TIAN Jun YING Min-gang et al. |
| Affiliation: | HUANG Su-ying,TIAN Jun,YING Min-gang,et al.School of Public Health,Fujian Medical University,Fuzhou 350004,China |
| Abstract: | Objective To screen the differentially expression genes related to metastasis of gastric carcer by gene chips,in order to identify marker gene candidates of gastric carcer metastasis in peripheral blood.Results The gene chips of Whole Human Genome Microarray(32050 human genes,phalanx) were used to detect the differential gene expression profiles in peripheral blood between gastric carcer patients with metastasis and with not.The results were analyzed by bioinformatics methods.Results 157 differentially expr... |
| Keywords: | Gastric cancer Peripheral blood Metastasis Gene chip Gene expression profile |
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