The thyrotropin-releasing hormone and dexamethasone suppression tests in the familial classification of depression |
| |
| Authors: | J E Fleming I Extein H A Sternbach A L Pottash M S Gold |
| |
| Affiliation: | Jan E. Fleming, B.Sc., is at the University of Toronto School of Medicine, Toronto, Canada, USA;Irl Extein, M.D., is at Fair Oaks Hospital, Summit, NJ, and Falkirk Hospital, Central Valley, NY, USA;Harvey A. Sternbach, M.D., is at Fair Oaks Hospital; Department of Psychiatry, Los Angeles VA Hospital, Brentwood Division; and UCLA Neuropsychiatric Institute, Los Angeles, CA, USA;L.C. Pottash, M.D., and Mark S. Gold, M.D., are at Fair Oaks Hospital; Falkirk Hospital; and Psychiatric Diagnostic Laboratories of America, Summit, NJ, USA |
| |
| Abstract: | Eighty-eight depressed patients who had received a dexamethasone suppression test (DST) and thyrotropin-releasing hormone (TRH) test were divided into four subgroups based on family history of psychiatric illness. Nonsuppression on the DST was found in 46% of familial pure depressive disease (FPDD) patients, 38% of sporadic depressive disease (SDD) patients, 38% of depressive spectrum disease (DSD) patients, and 50% of mixed depressive disease patients (patients with both a first degree relative with alcoholism and one with depression). A blunted thyroid-stimulating hormone response to TRH was found in 50% of FPDD patients, 56% of SDD patients, 47% of DSD patients, and 56% of mixed depressive disease patients. Neither the DST nor TRH test was found to distinguish significantly among the four familial subgroups of depression. |
| |
| Keywords: | Familial pure depressive sporadic depressive depressive spectrum disorder mixed depressive dexamethasone suppression test thyrotropin-releasing hormone test depression |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
