糖耐量减退患者的药物干预效果

目的 :探讨药物干预对 IGT患者的治疗效果及转归。方法 :随机选取 90例 IGT患者 ,分为双胍类药物治疗组、α-糖苷酶抑制剂治疗组和饮食、运动干预组。干预前后测定 FPG、2 h PG、TC、TG、L DL 和 HDL。结果 :双胍组FPG、2 h PG与干预前相比均有明显下降 (P<0 .0 0 1) ,与饮食运动组相比亦有明显下降 (P<0 .0 0 1) ,差异有显著性。双胍组中糖耐量转为正常者 9例 (30 % ) ,与饮食运动组比较差异有显著性 (P<0 .0 5 )。糖苷酶抑制组 FPG、2 h PG与干预前相比均有明显下降 (P<0 .0 0 1) ,与饮食运动组相比亦有明显下降 (P<0 .0 0 1) ,差异有显著性。糖苷酶抑制组中糖耐量转为正常者 8例 (2 6 .7% ) ,与饮食运动组比较差异有显著性 (P<0 .0 5 )。结论 :对 IGT进行双胍类药物 ,α-糖苷酶抑制剂治疗可有效降低其空腹和餐后血糖 ,并能增加其向 NGT转化。

The Effect of Intervention by Drugs on IGT patients

Objective To investigate the effect and turn over of intervention by drugs on IGT patients.Methods 90 IGT patients were selected in random, and divided into three groups: diet plus exercise group, Acarbose group and Metformin group. Determinating FPG、2 h PG、TC、TG、LDL and HDL before and after intervention.Results By the end of the study, both FPG and 2 h PG significantly decreased in the Metformin group (P<0.001), they significantly decreased compared with diet plus exercise group (P<0.001), and 9 IGT patients (30 %) became NGT, significantly increased compared with diet plus exercise group (P<0.05). both FPG and 2 h PG significantly also decreased in the Acarbose group(P<0.001), they significantly decreased compared with diet plus exercise group (P<0.001), and 8 IGT patients (26.7 %) became NGT, significantly increased compared with diet plus exercise group (P<0.05).Conclusion Acarbose and Metformin can effectly lower IGT patients’ FPG and 2hPG, and convert to NGT.