| 降纤酶与其他药物改善急性脑梗死患者神经功能缺损对照研究的Meta分析 |
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| 引用本文： | 蒋亚斌,朱宁. 降纤酶与其他药物改善急性脑梗死患者神经功能缺损对照研究的Meta分析[J]. 中国组织工程研究与临床康复, 2004, 8(16): 3156-3157 |
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| 作者姓名： | 蒋亚斌 朱宁 |
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| 作者单位： | 暨南大学附属第一医院急诊科,广东省广州市,510632 |
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| 摘 要： | 目的:了解降纤酶与其他药物治疗急性脑梗死(acutecerebralinfarc-tion,ACI)疗效的差异。方法:应用Meta分析对10项研究降纤酶与其他药物治疗ACI的效果进行同质性检验和合并效应量的估计。结果:①同质性检验:χ2=6.8452,自由度为9,P>0.05。②合并效应量的估计:OR合并=3.2353,OR合并95%可信区间为2.21～4.74。OR合并的检验:χ2=36.2,P<0.001。结论:降纤酶治疗ACI的疗效显著优于目前常用药物,其在适应证、治疗剂量、给药方法及用药时限等方面与临床疗效的关系有待进一步研究。
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| 关 键 词： | 脑梗塞 酶类 对照临床试验 统计学 |
Meta-analysis:defibrase vs other drugs in treatment of acute cerebral infarction |
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| Abstract. Meta-analysis:defibrase vs other drugs in treatment of acute cerebral infarction[J]. Journal of Clinical Rehabilitative Tissue Engineering Research, 2004, 8(16): 3156-3157 |
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| Authors: | Abstract |
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| Abstract: | AIM: To compare debriase with other drugs in the treatment of acute cerebral infarction(ACI).METHODS: A mcta-analysis on 10 studies was conducted to compare defibrase and other drugs in the treatment of ACI.RESULTS: ① Homogneity analysis: X2 = 6. 845 2, freedom was 9, and P ＞ 0.05. ② Calculation of common estimate: OR 3. 235 3, with a 95% confidence interval between 2.21 and 4.74. Common estimate:X2=36.2, P ＜ 0.001.CONCLUSION: The result of difference analysis indicated a significant superior effect of defibrase than other drugs in the treatment of ACI. Further researches providing objective assessments are necessary for investigating the clinical application of defibrase for the treatment of ACI, specifically in the area of effective dosage, method, and interval. |
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