血容量调节的数字仿真研究

为研究血容量变化对心脏泵血功能的影响，建立了包含量个血容量调节机制的心血管系统的计算机模型。提出了评价心脏工作状态的指标－心脏能量材料系数（ＥＶ）。ＥＶ为单位时间为内心脏能耗与心室舒张末期容积的乘积。仿真实验表明：心肌收缩力不足时为维持下沉动脉压、务容量将增加，心脏体积和心脏能耗也随之增加，结果不报道相符；对于确定的心室收缩能力。在动脉维持不挛民政部下，ＥＶ最小所对应的以及状态临床所观察到的状态相

Simulation Study on the Blood Volume Feedback Control

To describe the relationship between blood volume and the cardiac function mathematically, a computer cardiovascular model,was developed including a systemic circulation, a heart and a pulmonary model and a blood volume feedback control.Simulation results indicate that the chronic heart failure could be compensated by increasing the blood volume to maintain the proper arterial pressure.Deterioration in heart failure causes an increase in blood volume, as well as increases in heart volume and cardiac energy consumption. These results are in agreement with the clinical data and results reported in the literature.The simulation also shows that for a predetermined ventricular contractility, an adequate increase in blood volume will increase the heart volume but decrease the cardiac energy consumption and lead the heart to work in an optimum condition.