普罗布考和科素亚对兔血管成形术后生长因子的影响

目的：研究普罗布考和科素亚对兔血管成形术后再狭窄的预防作用及其对生长因子表达的影响。方法：雄性新西兰白兔40只，随机分为高胆固醇组、普罗布考组、科素亚组和联合用药组。1周后进行髂动脉球囊拉伤术，术后4周进行弹力纤维染色，用免疫组化检测血管胰岛素样生长因子-Ⅰ受体（insulin-like growth factor-Ⅰ receptor，IGF-IR）和内皮生长因子（vascular endothelial growth factor，VEGF）表达。结果：与高胆固醇组相比，普罗布考组、科素亚组和联合用药组管腔面积明显扩大（P〈0．01），内膜面积明显减少（P〈0．05），IGF-IR和VEGF表达明显减少（P〈0．01），但3组间相比差异无统计学意义（P〉0．05）。结论：普罗布考和科素亚可以显著减轻兔髂动脉血管成形术后再狭窄的形成，抑制IGF—IR和VEGF的表达。联合用药与单独用药之间差异无统计学意义。

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Objective To investigate the effect of probucol and losartan on the prevention of restenosis after balloon angioplasty in hypercholesterolaemic rabbits,and to examine the expression of growth factors.Methods Forty male New Zealand white rabbits were randomly divided into high cholesterol diet group,probucol group,losartan group and combined drugs group.After one week of diet,all rabbits were injured on iliac arteries with balloon.Four weeks after the injury,the morphology of the iliac arteries of the rabbits were observed,and the insulin-like growth factor-I receptor (IGF-IR)and vascular endothelial growth factor(VEGF) were examined by immunohistochemical methods.Results Compared with the high cholesterol diet group,the lumen areas of the probucol group,losartan group and combined drugs group were larger(P<0.01),the intimal areas were smaller(P<0.05),and the expression of IGF-IR and VEGF significantly decreased(P<0.05).There was no statistically significant difference among the three groups.Conclusion Probucol and losartan can prevent the restenosis of rabbits' iliac artery from balloon injury,and inhibit the expression of IGF-IR and VEGF.There is no statistical difference between combined drugs and single drug administration.