| PD-1/PD-L负性协同刺激途径与慢性病毒感染 |
| |
| 引用本文： | 周承,陈智.PD-1/PD-L负性协同刺激途径与慢性病毒感染[J].国际流行病学传染病学杂志,2007,34(1):41-45. |
| |
| 作者姓名： | 周承 陈智 |
| |
| 作者单位： | 310003,杭州,浙江大学医学院附属第一医院传染病研究所 |
| |
| 基金项目： | 国家自然科学基金(30471537) |
| |
| 摘 要： | PD-1(programmed death 1)是用消减杂交技术从发生程序性死亡的T细胞株中分离得到的一种跨膜蛋白,是一种负向协同刺激分子。PD-1及其配体PD-L所介导的信号在维持机体自身免疫耐受中具有重要意义,最新研究发现该途径与宿主的病毒感染慢性化密切相关。此文在论述PD-1及其配体PD-L的基本结构、表达和生物学功能的基础上,进一步就其与病毒感染的关系、作用及其在抗慢性病毒感染治疗中应用的潜在前景予以综述。
|
| 关 键 词： | T淋巴细胞 PD-1/PD-L途径 慢性病毒感染 封闭疗法 |
The PD-1/PD-L pathway in chronic viral infection |
| |
| ZHOU Cheng,CHEN Zhi.The PD-1/PD-L pathway in chronic viral infection[J].International Journal of Epidemiology and Infectious Disease,2007,34(1):41-45. |
| |
| Authors: | ZHOU Cheng CHEN Zhi |
| |
| Abstract: | The coinhibitory signaling PD-1/PD-L has been shown to play critical roles in immunological tolerance.Recent studies revealed persistant viral infection was related with this pathway.Blockade of the inhibitory molecules PD-1 and PD-L can restore the function of exhausted CD8+ T cells during chronic viral infection.The structures,expressions and their biological effects of PD-1 and PD-L were summarized.Furthermore,the relationship of this inhibitory pathway with chronic viral infections and its potential as treatment target were reviewed in detail. |
| |
| Keywords: | T lymphocytes PD-1/PD-L pathway Chronic viral infection Blocking treatment |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
