珍珠层／聚乳酸重组人工骨的研制及其相关性能检测

目的 研制性能优良的人工骨料并评价其相关性能。方法 将珍珠层、聚乳酸、氯化钠按比例复合，利用模压增强法制备重组人工骨（NPCB）材料，检测其孔隙率、孔径、生物力学强度等性能参数，并与有机溶剂注模法制备的材料进行比较。结果 研制的NPCB材料孔隙率47．65％、孔径为218．83μm、压缩强度为16．10MPa、弯曲强度为60．18MPa。与有机溶剂注模法相比，模压增强法可使材料的压缩强度提高10倍以上。结论 模压增强法可有效地增强NPCB的生物力学强度；NPCB材料的孔隙率、孔径、生物力学强度等性能均符合骨替代材料的要求。

Development of artificial bone made from nacre and polylactic acid and property assessment.]

OBJECTIVE: To explore a new bone substitute for bone grafting and evaluate its properties. METHODS: Pressurized molding of nacre, polylactic acid and NaCl that were proportionally mixed was performed to obtain the bone grafting material, and its properties as porosity, pore size and mechanical strength were compared with those of the material prepared by solvent casting. RESULTS: Compared with that of the material made by solvent casting, the mechanical strength of the new artificial bone material was 10-fold stronger with an average porosity rate of 47.65%, pore size of 218.83 micrometer compressive strength of 16.10 MPa and flexural strength of 60.18 MPa. CONCLUSION: The new technique adopted in this study can effectively enhance the biomechanics of the artificial bone material, which can be suitable for repairing bone defect.