| 胰岛素依赖型糖尿病HLA—DR9遗传异质性的初步探讨 |
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| 引用本文： | 徐春生 陈浩量. 胰岛素依赖型糖尿病HLA—DR9遗传异质性的初步探讨[J]. 广东医学, 1998, 19(12): 901-901 |
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| 作者姓名： | 徐春生 陈浩量 |
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| 作者单位： | 中山医科大学孙逸仙纪念医院内分泌科!510120(徐春生，陈浩量，刘顺莲，黎峰，程桦，钟光恕)，中 (傅祖植) |
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| 基金项目： | 广东省科委重点科技攻关项目 |
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| 摘 要： | 目的：探讨胰岛素依赖型糖尿病遗传异质性，方法：采用序列特异性ＰＣＲ对６４例ＩＤＤＭ（包括１４岁前起病组１７例，１５－３０岁起病组３０例和３１岁后起病组１７例）和７２例健康对照进行ＨＬＡ－ＤＲ９基因分型，结果：１４岁前起病组１５－３０岁起病由３１岁后起病组ＩＤＤＭ病人中ＨＬＡ－ＤＲ９频率分别为５８．８％，４６．７％和３５．３％各组间比较差异无显著性意义（Ｐ〉．０５），１４岁前起病组与对照组（３３．３
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| 关 键 词： | IDDM 糖尿病 遗传异质性 HLA DR9 |
A Preliminary Study on HLA-DR_9-related Heterogeneity of Insulin-dependent Diabetes Mellitus |
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| Xu Chunsheng,Chen Haoliang,Liu Shunlian,et al.. A Preliminary Study on HLA-DR_9-related Heterogeneity of Insulin-dependent Diabetes Mellitus[J]. Guangdong Medical Journal, 1998, 19(12): 901-901 |
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| Authors: | Xu Chunsheng Chen Haoliang Liu Shunlian et al. |
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| Abstract: | Objective:Studying the heterogeneity of insulin dependent diabetes mellitus.Metods:Sequence-specific PCR was performed for HLA-DR9 genotyping in 64 IDDM patients(including 17 cases in group A with onsed of deabeten before 14 years of lok,30 cases in group B between 15-30 and 17 cases ingroup C after 31)and 72 healthy controls.Results:The frequency of HLA-DR+ in group A,B and C was 58.8k,46,7%and 35.3% respectively .The differences between three subgroups of IDDM were not statistically aingificant(P>0.05).Compring group A and control(33.3%),P-0.0517.Coonchusion:There might be different genetic background in childhood-onset and adult-onset IDDM. |
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| Keywords: | IDDM Heterogeneity HLA-DR_9 |
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