髂内动脉化疗栓塞药泵置入联合手术治疗浸润性膀胱癌

目的：探讨治疗浸润性膀胱癌的有效方法。方法：对60例经手术、病理证实并获随访的浸润性膀胱癌患者分为A、B两组，A组30例为髂内动脉化疗栓塞药泵置入后手术治疗组，B组30例为单纯手术治疗组，分析比较两组患者术后复发率、病死率的差异，了解介入联合手术治疗的效应。结果：A组患者术前髂内动脉化疗栓塞后完全缓解率（CR）为16．7％（5／30），部分缓解率（PR）为70％（21／30），有效率（CR＋PR）为86．7％。术后切除标本病理检查光镜下可见大片状癌细胞变性坏死，间质见炎细胞浸润。A组死亡4例（13．3％），B组死亡8例（26．7％）。A组复发6例（20％），B组复发14例（46．7％）。结论：髂内动脉化疗栓塞药泵置人后手术治疗浸润性膀胱癌，安全有效，能显著提高膀胱癌的疗效。

Internal iliac artery chemotherapy plus embolization and infusion pump chemotherapy combined with surgical operation for the treatment of invasive bladder cancer

Objective： To explore the effective therapy for invasive bladder cancer. Methods： Sixty patients with invasive bladder cancer were divided into A group and B group in random sample. Intra-intemal lilac-arterial chemotherapy and infusion pump chemotherapy combined with surgical operation were performed in A group. Surgical operation were simply performed in B group. The difference of the recrudescence rate and sutural rate between two groups were analyzed. The effect of intra-arterial chemotherapy combined with surgical operation at the same time was evaluated. Results：The complete response rate （CR） and the partial response rate （PR） were 16.7% （5/ 30） and 70% （21/30） respectively. Tumor response rate （CR＋ PR） was 86.7%. Pathomorpholoical features, including large palehy necrosis, degeneration, and inflamematory changes of carcinoma tissue, were founded in A group at the same time. In A group, 6 eases relapsed （20%） and 4 cases died （13.3%）. In B group, 14 eases relapsed （46.7%） and 8 eases died （26.7%）. Conelusion：The eombinability of intra-intemal iliac-arterial, infusion pump chemotherapy and surgical operation are safe, effective for invasive bladder cancer. It can improve the sturvive and life quality of patients.