Monoamine effects on neuronal recovery cycles in globus pallidus,caudate nucleus,and substantia nigra |
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| Authors: | Dr. N. Dafny S. Gilman |
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| Affiliation: | (1) Department of Neurobiology, The University of Texas Medical School at Houston, 77025 Houston, TX, USA;(2) Department of Neurology, College of Physicians and Surgeons, Columbia University New York, New York, USA |
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| Abstract: | Summary In freely moving rats, averaged evoked potentials (AAER) to paired click stimuli delivered at varying interstimulus intervals were recorded with semi-microelectrodes simultaneously in globus pallidus (GP), caudate nucleus (CN), and substantia nigra (SN). The effects of intrapentoneal injection of reserpine and L-Dopa on the neuronal recovery cycles were studied. The results indicate that these drugs have different effects in the various structures. The major difference is a lack of effect in SN in contrast to substantial effects in GP and CN. This finding is compatible with the hypothesis that monoamines may be synthesized in SN but exert their major pharmacological action in the GP and CN.Supported, in part, by USPHS Grants NS 05184 and NS 2552, and The Eli Lilly Company.With 2 Figures |
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