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| 20株阴沟肠杆菌耐药性及耐复方磺胺甲(口恶)唑相关基因研究 | |
| 引用本文： | 蔡培泉,黄支密,王春新,糜祖煌. 20株阴沟肠杆菌耐药性及耐复方磺胺甲(口恶)唑相关基因研究[J]. 中国抗生素杂志, 2007, 32(7): 438-440 |
| 作者姓名： | 蔡培泉 黄支密 王春新 糜祖煌 |
| 作者单位： | 1. 南京医科大学附属无锡第一医院,无锡,214002 2. 解放军98医院,湖州,313000 3. 无锡市克隆遗传技术研究所,无锡,214026 |
| 摘 要： | 目的 探讨临床分离的阴沟肠杆菌耐药性和耐复方磺胺甲(口恶)唑(SMZ/TMP)相关基因存在状况.方法 采用ATB药敏试验板微量肉汤法测定临床分离的20株阴沟肠杆菌对20种抗菌药物的敏感性,采用PCR检测耐复方磺胺甲(口恶)唑相关基因sull、dfrA1和dfrA17.结果 20株菌对亚胺培南和美罗培南均敏感,对其他抗菌药物的不敏感率在25.0%～100%之间.sulⅠ、dfrA1和dfrA17基因阳性率为85.0%(17/20)、5.0%(1/21)、60.0%(12/20).结论 阴沟肠杆菌具明显的多重耐药特征.耐复方磺胺甲(口恶)唑相关基因携带率很高. |
| 关 键 词： | 阴沟肠杆菌 复方磺胺甲(口恶)唑 耐药基因 |
| 文章编号： | 1001-8689(2007)07-0438-03 |
| 修稿时间： | 2006-01-23 |
Study on the resistance and the sulfamethoxazole/trimethoprim-resistant associated genes in Enterobacter cloacae |
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| Cai Pei-quan,Huang Zhi-mi,Wang Chun-xin,Mi Zu-huang. Study on the resistance and the sulfamethoxazole/trimethoprim-resistant associated genes in Enterobacter cloacae[J]. Chinese Journal of Antibiotics, 2007, 32(7): 438-440 | |
| Authors: | Cai Pei-quan Huang Zhi-mi Wang Chun-xin Mi Zu-huang |
| Abstract: | Objective To investigate the antimicrobial resistance and the sulfamethoxazole/trimethoprim resistant associated genes in Enterobacter cloacae.Methods Microdilution tests were performed to detect the susceptibility of 20 kinds of antimicrobial agents against 20 strains of Enterobacter cloacae.The sulI,dfrA1 and dfrA17 genes were analyzed by PCR.Results There is no strain resistant to imipeneam and meropenem.The resistant rates to other antimicrobial agents between 25.0% and 100%.The positive rates of sulI,dfrA1 and dfrA17 genes were 85.0%(17/20),5.0%(1/21) and 60.0%(12/20) respectively.Conclusion The 20 strains were multiple-drug-resistance.There were very high positive percentages of sulI and dfrA17 genes in Enterobacter cloacae isolated from hospital. |
| Keywords: | Enterobacter cloacae Sulfamethoxazole/trimethoprim(SMZ/TMP) Drug-resistant genes |
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