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| 急性脑梗死患者血清sICAM-1变化及临床意义 | |
| 引用本文： | 杜怡峰,徐勇,陈峰,谢琰臣. 急性脑梗死患者血清sICAM-1变化及临床意义[J]. 山东医药, 2003, 43(1): 4-5 |
| 作者姓名： | 杜怡峰 徐勇 陈峰 谢琰臣 |
| 作者单位： | 1. 山东省立医院 2. 济南军区第三干休所卫生队 3. 平邑县中医院 4. 青岛大学医学院附属医院,山东,青岛,226003 |
| 基金项目： | 山东省科委科研基金资助项目 (No.1999E14 ) |
| 摘 要： | 为探讨是粘附分子－1（ICAM－1）与急性脑梗死（ACI）发生发展的关系，应用酶联免疫吸附试验（ELISA）以双抗夹心法检测了48例ACI患者发病后24小时内，第3天，第7天，第14天血清内可溶性ICAM－1（sICAM-1）含量的变化，同时采用葡萄糖氧化酶法和硫代巴比妥酸法分别测定了血糖和丙二醛（MDA）水平。结果显示，ACI发病后2周的血清sICAM-1含量明显高于正常对照组（P＜0．05），发病后24小时内即见血清sICAM-1水平增高，至第3天达最高水平，以后逐渐降低。血sICAM-1水平与MDA和血糖呈正相关。认为ICAM－1参与了ACI的病理损伤过程，氧化应激和高血糖可能是加重这一病理损伤过程的重要因素。 |
| 关 键 词： | 脑梗死 细胞间粘附分子－1 诊断 |
| 修稿时间： | 2002-10-18 |
Change and significance of serum sICAM-1 in patients with acute cerebral infarction |
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| Du Yifeng,Xu Yong,Chen Feng,et al. Change and significance of serum sICAM-1 in patients with acute cerebral infarction[J]. Shandong Medical Journal, 2003, 43(1): 4-5 | |
| Authors: | Du Yifeng Xu Yong Chen Feng et al |
| Abstract: | To investigate the relationship between the levels of soluble intercellular adhesion molecule-1(sICAM-1)and the pathogenesis of acute cerebral infarction.The changes of serum sICAM-1 in 48 patients with acute cerebral infarction were observed by an enzyme-linked immunosorbent assay (ELISA).Results showed that the levels of serum sICAM-1 in patients with cerebral infarction 14 days after the onset was higher than that in normal controls(P<0.05).sICAM-1 began to increase with in 24h and peaked at 3 days after the cerebral infarction,then decreased progressively to the normal level.The sICAM-1 concentrations had a positive correlation with the contents of malondialdehyde(MDA) and blood sugar.This suggests that ICAM-1 is closely related to the development of acute cerebral infarction,oxidative stress and high blood sugar might play a key role in the pathogenesis. |
| Keywords: | Cerebral infarction Intercellular adhesion molecule-1 |
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