| 二硫化碳慢性接触对儿茶酚胺类代谢的影响 |
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| 引用本文： | 杨杏芬,庄志雄,马林,谭炳炎.二硫化碳慢性接触对儿茶酚胺类代谢的影响[J].中华劳动卫生职业病杂志,1996(1). |
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| 作者姓名： | 杨杏芬 庄志雄 马林 谭炳炎 |
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| 作者单位： | 中山医科大学卫生学院，新加坡国立大学社区、职业与家庭医学系 |
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| 摘 要： | 采用综合累积暴露指数（ＩＣＥ），将工人接触ＣＳ２浓度和接触期限结合起来定量评价暴露强度，并检测尿中２－硫代噻唑烷－４－羧酸（ＴＴＣＡ）和儿茶酚胺类神经递质代谢产物的含量。结果显示：接触组尿中ＴＴＣＡ增高，存在剂量－效应关系；高接触组高香草酸（ＨＶＡ）和香草扁桃酸（ＶＭＡ）排泄减少。这两种儿茶酚胺代谢产物与ＣＳ２浓度及工龄虽未显示有显著意义的相关，但与ＩＣＥ及ＴＴＣＡ之间却呈现统计学上的相关关系，表明长期接触ＣＳ２对儿茶酚胺类神经递质代谢有一定的干扰作用。
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| 关 键 词： | 二硫化碳 儿茶酚胺类神经递质 内接触 神经毒性 |
Effectofchronicexposuretocarbondisulphideoncatecholaminemetabolisminworkers |
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| YangXingfen,ZhuangZhixiong,MaLin,et al..Effectofchronicexposuretocarbondisulphideoncatecholaminemetabolisminworkers[J].Chinese Journal of Industrial Hygiene and Occupational Diseases,1996(1). |
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| Authors: | YangXingfen ZhuangZhixiong MaLin |
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| Institution: | YangXingfen,ZhuangZhixiong,MaLin,etal.SchoolofPublicHealth,SunYat-SenUniversityofMedicalSciences,Guangzhou510089 |
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| Abstract: | ThepresentstudywasundertakentoexaminetherelationshipsamongCS2exposure,urinary2-thiothiazolidine-4-carboxylicacidandtwomajormetabolitesofcatecholamine,homovanilicacid(HVA)andvanilylmandelicacid(VMA),inagroupofworkerschronicalyexposedtodiferentconcentrationofCS2inalargeviscoserayonplant.Inordertohaveabeterjudgementoncumulativeexposureintensity,theindexofcumulativeexposure(ICE)whichwastheproductofexposuredosagemultipliedbydurationofexposureyear.TheresultsshowedthatthegeometricmeanconcentrationsofCS2intheplantrangedfrom8.47to63.80mg/m3,andabout50%ofthestudiedpopulationhadbeenrepeatedlyexposedtoCS2ofaconcentrationexceededthehygienicstandardofChina(10mg/m3).UrinaryTTCAwasincreasedinthoseexposedworkerswithdose-responserelationship.Therewasasignificantlylow-erlevelofHVAandVMAintheCS2workersofhighexposedgroup.AlthoughtherewerenostatisticalcorelationsamongtwocatecholaminemetabolitesandthemeanCS2concentration,andyearsofemployment,significantdose-efectrelationshipswereobservedamongthesetwometabolitesandICEandTTCA.Theresultssuggestedthatlong-termexposuretoCS2mayinterferewithcatecholamineneurotransmitermetabolism. |
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| Keywords: | CarbondisulphideCatecholamineInternalexposureNeurotoxicity |
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