静脉滴注利奈唑胺致白细胞及中性粒细胞减少1例

1例57a女性患者,既往患慢性肾功能衰竭,行持续不卧床腹膜透析治疗。因急性腹膜炎静脉滴注利奈唑胺0.6g,bid。用药2d后,出现白细胞及中性粒细胞减少,WBC2.43×109·L-1,N0。立即停药,给予粒细胞集落刺激因子100μg对症治疗。2d后复查血常规WBC9.10×109·L-1,N41.6%。之后换用其他抗菌药物,未出现白细胞及中性粒细胞减少。

One case of leucopenia and neutropenia caused by intravenous drip of linezolid

A 57-year-old female suffered from chronic renal failure and was treated with continuous ambulatory peritoneal dialysis （CAPD）. The patient received an intravenous infusion of linezolid 0.6 g twice daily for the treatment of acute peritonitis. Two days later, the patient developed leucopenia （WBC 2.43×109·L-1） and neutropenia （N 0）. The medication was stopped immediately, and the patient was treated with granulocyte colony-stimulating factor （G-CSF） 100 μg. Two days later, the WBC count increased to 9.10×109·L-1 and N 41.6%. Linezolid was replaced by other antimicrobial drugs, and leucopenia and neutropenia didn＇t reoccur.