| 两种剂量青霉胺治疗肝豆状核变性的临床观察 |
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| 引用本文： | 温兆春,王如明,孙文秀,王学禹,马禄兴. 两种剂量青霉胺治疗肝豆状核变性的临床观察[J]. 中国实用儿科杂志, 2001, 16(3): 165-166 |
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| 作者姓名： | 温兆春 王如明 孙文秀 王学禹 马禄兴 |
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| 作者单位： | 1. 山东省立医院儿科
2. 山东省蒙阴县人民医院 |
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| 摘 要： | 目的
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| 关 键 词： | 肝豆状核变性 |
| 文章编号： | 1005-2224(2001)03-0165-02 |
| 修稿时间： | 2000-10-20 |
The study of two kinds ofdoses of penicillamine in treating hepatolenticuar degeneration |
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| Wen Zhaochun,Wang Ruming,Sun Wenxiu,et al.. The study of two kinds ofdoses of penicillamine in treating hepatolenticuar degeneration[J]. Chinese Journal of Practical Pediatrics, 2001, 16(3): 165-166 |
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| Authors: | Wen Zhaochun Wang Ruming Sun Wenxiu et al. |
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| Affiliation: | Wen Zhaochun,Wang Ruming,Sun Wenxiu,et al.Shandong Provice Hospital,Jinan 250021 |
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| Abstract: | Objective To determine the best plan with penicillamine in treating the patients with hepatolenticular degeneration. Methods Use two kinds of doses of penicillamine to treat two groups of the patients with hepatolenticular degeneration,one group using small dose[5～10mg/(kg·d)] and the other moderate dose[11～16mg/(kg·d)]. Observe the patients'clinical features, determine the average amount of daily urine copper of every week(total 8 weeks)and then draw the curve of urine copper and side effects. Results (1) The effect of copper driving of the moderate dose was better than that of the small dose during the first six weeks of treatment(P＜0.01). (2) After six weeks, the effects of the two doses were relatively stable(P＞0.05). (3)The difference of the side effects between the two groups was not clear. Conclusion The study suggests that we had better use moderate dose to treat patients with hepatolenticular degeneration in acute stage( the first six weeks) and small dose after acute stage( after six weeks). |
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| Keywords: | Hepatolenticular degeneration Penicillamine Therapeutic dosage |
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