甘精胰岛素联合口服降糖药治疗初诊2型糖尿病的临床观察

目的：观察不同干预方式对初诊2型糖尿病患者的血糖控制情况以及血糖达标时间、低血糖发生例数的作用。方法：将符合纳入标准的60例初诊2型糖尿病患者随机分为A组（甘精胰岛素联合口服二甲双胍片或阿卡波糖片组）30例，B组（预混胰岛素组）30例。治疗4周，观察血糖变化情况，并记录血糖达标时间和低血糖反应例数。结果：除A组1例及B组2例外，其余患者治疗后空腹血糖、餐后2h血糖均达到控制目标。在治疗过程中A组1例及B组7例出现低血糖。结论：两组治疗均能使初诊2型糖尿病患者的血糖达标（P〈0．05），血糖达标时间无明显差异（P〉0．05），但两组出现低血糖的例数有显著性差异（P〈0．05）。

Clinical Observations on Insulin Glargine Combined with Oral Hypoglycemic Agents in Treatment of Type 2 Diabetes of Preliminary Diagnosis

Objective:To observe the glucose control status of the patients with type 2 diabetes of preliminary diagno-sis, the time of glucose reaching the standard and the cases of hypoglycemia incidence by different intervention methods. Methods:Sixty cases which were in accordance with the inclusion criteria of type 2 diabetes of preliminary diagnosis were randomly divided into group A (insulin glargine and metformin tablets or acarbose) and group B (premixed insu-lin). After 4 weeks of the treatment, the glucose change status, the time of reaching the standard of glucose and the cases of hypoglycemic reaction were observed and recorded. Results:Fasting glucose and postprandial glucose of 2 h could reach the control standard except 1 case in group A and 2 cases in group B. During the course of the treatment, 1 case in group A and 7 cases in group B appeared hypoglycemia. Conclusion:The two different kinds of intervention methods can make glucose of the patients with type 2 diabetes of preliminary diagnosis normal (P < 0.05). There is no difference between the two groups in time of reaching the standard (P > 0.05) and there is significant difference between the two groups in the cases of hypoglycemia (P < 0.05).