| Fas在大肠癌及癌旁组织的不同表达及意义 |
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| 引用本文： | 张继红,孙波,姜晶,王彩芹,史忠新,陈永利,石家琛.Fas在大肠癌及癌旁组织的不同表达及意义[J].中国热带医学,2005,5(8):1627-1628. |
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| 作者姓名： | 张继红 孙波 姜晶 王彩芹 史忠新 陈永利 石家琛 |
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| 作者单位： | 北华大学附属医院,吉林,吉林,132011 |
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| 摘 要： | 目的研究Fas在人体大肠癌及癌旁组织中的表达. 方法应用SP免疫组化方法（链霉菌抗生物素蛋白-过氧化物酶连接法）对49例大肠癌及癌旁组织中的Fas基因的表达进行检测. 结果凋亡基因Fas在大肠癌组织中的阳性表达率高于癌旁组织（P＜0.05）,且高分化腺癌组织中的阳性表达率高于癌旁组织（P＜0.05）,但在不同分级的大肠癌及其癌旁组织之间的阳性率无明显差异. 结论分化低的大肠腺癌癌旁组织中的细胞凋亡活动较活跃,有利于肿瘤的浸润与破坏.
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| 关 键 词： | 大肠癌 凋亡基因 Fas免疫组化 |
| 文章编号： | 1009-9727(2005)08-1627-02 |
| 收稿时间： | 09 12 2005 12:00AM |
| 修稿时间： | 2005年9月12日 |
The expression and significance of apoptotic genes Fas in large intestine cancer and neighboring tissues |
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| ZHANG Ji-hong,SUN Bo,JIANG Jing,et al..The expression and significance of apoptotic genes Fas in large intestine cancer and neighboring tissues[J].China Tropical Medicine,2005,5(8):1627-1628. |
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| Authors: | ZHANG Ji-hong SUN Bo JIANG Jing |
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| Institution: | Affiliated Hospital of Beihua University, Jilin 132001, Jilin, P. R. China |
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| Abstract: | Objective To investigate the expression of Fas in colonic cancer and near-by tissues. Methods The expression of Fas genes in colonic cancer and near-by tissues of 49 cases was determined by applying a method of SP immunohistochemical (streptomycin avidin-peroxidase connection). Results The results revealed that the positive expressive rate of apoptotic genes Fas in cilonic cancer was higher than in near-by tissues (P<0.05) and the expression rate in the tissuesof well-differentiated adenocar cinoma was also higher than that in the near-by tissues(P<0.05). The positive rate in colonic cancers of different grade was not significafltly different from that in their near-by tissues. Conclusion The apoptosis cells are more active in the near-by tissues of colonic adenocarcinoma of low-differentiation,which is in favour of infiltroition and diffusion of tumor. |
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| Keywords: | Colonic cancer Apoptotie genes Fas Immuno histochemistry |
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