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Patients with Pulmonary Tuberculosis Develop a Strong Humoral Response against Methylated Heparin-Binding Hemagglutinin |
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| Authors: | Stefania Zanetti Alessandra Bua Giovanni Delogu Cinzia Pusceddu Maristella Mura Franca Saba Piero Pirina Carlo Garzelli Cono Vertuccio Leonardo A Sechi and Giovanni Fadda |
| Abstract: | Reactivities of human sera against selected recombinant Mycobacterium tuberculosis antigens were assessed by enzyme-linked immunosorbent assay. The results obtained indicate that patients with tuberculosis (TB) do not develop a strong humoral response against PE_PGRS and PPE proteins or against the Ag85B and heparin-binding hemagglutinin (HBHA) recombinant antigens. Conversely, purified methylated HBHA was strongly recognized by sera obtained from TB patients compared to controls. |
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