补肾健脾中药对极限运动后肾脏功能的保护

背景运动成绩的提高需要超越极限运动来获取,如何在取得优异成绩的前提下保护运动员身体健康.目的采用中国传统中医方法,减少运动员在极限运动后肾脏功能受到损害.设计以体育教育专业学生为对象.随机对照观察.单位曲阜市中医院中医内科和曲阜师范大学体育科学学院.对象于2004-04-20从曲阜师范大学2000级体育教育专业学生16个自然小班中随机抽取2个自然小班,每班各抽取20名.方法把40名学生按自然小班1,2班分为实验班和对照班.2004-04-24极限训练一次后15～20 min及晨起即刻取尿液少许测试.2004-05-24以同样的负荷强度、同样的方法测试和处理.期间实验组每天3次服补肾健脾中药胶囊(其主要成分包括怀山药、何首乌、仙灵脾、枸杞子、绞股兰、刺五加、丹参、柴胡等,0.3g/粒),每次6粒.采用放射免疫法测定尿糖蛋白、β2微球蛋白、尿白蛋白、免疫球蛋白.主要观察指标两组学生极限运动后和次日晨起尿蛋白含量服药前后的比较.结果两组学生均完成整个实验过程,所有数据无一脱落.①第1次实验即服药前,受试者极限运动后各种尿蛋白的含量均明显增加,次日晨起各类蛋白自然恢复情况有明显的差异其中尿白蛋白的恢复最快,基本恢复到正常值;尿β2微球蛋白和免疫球蛋白的恢复比较明显;尿糖蛋白无明显的恢复现象.②第2次实验后,实验组和对照组比较发现,补肾健脾中药对极限运动后尿蛋白恢复有明显的影响尿白蛋白因自然恢复太快无法显示出12 h药的作用;促进β2微球蛋白和免疫球蛋白的恢复;对尿糖蛋白的恢复作用明显,实验组和对照组相比差异有显著性(实验组基本恢复到正常值,对照组基本无变化).结论极限负荷强度运动后尿蛋白明显增加,并且4种蛋白的自然恢复情况呈规律性变化,补肾健脾中药可促进极限运动后尿蛋白恢复至正常值,提示其对肾功能的保护作用.

Protection of kidney-and-spleen-strengthening Chinese drug on renal function following maximal exercise

BACKGROUND:The improvement of athletic achievements needs a super-limited exercise to gain,how to protect athletics health under the prerequisite of gaining excellent achievements?OBJECTIVE:To reduce the injury of athletic renal function following maximum exercise by using traditional Chinese medicinal methodDESIGN:A randomized and controlled trial,taking students majoring in sports education specialty as subjects.SETTING:Internal Medicinal Department of Traditional Chinese Medicine (TCM) Hospital of Qufu Hospital of Traditional Chinese Medicine and Sports Education College of Qufu Normal University.PARTICIPANTS :Two small natural classes were randomly drown up from 16 small natural classes of 2000 grade in Sports Education College of Qufu Normal University, with 20 students in each class, on April 20, 2004.METHODS:All 40 students were according to natural class divided as experimental class and control class.The urine specimens for test were collected 15-20 minutes after one time maximum loading training on April24,2004 and immediately after morning getting-up. The procedure was performed once more on May 24. During the process the students in experimental group had taken the capsule of kidney-and-spleen-strengthening Chinese drug (KSSD, containing mainly Rhizoma Dioscoreae, Radix Polygoni Multiflori, Herba Epimedii, Fructus Lycii, Gynostamma Pentaphyllum,Radix Acanthopanacis Senticosi,Radix Salviae Miltiorrhizae,Radix Bupleuri, etc., 0.3 g/pellet), 6 pellets, 3 times a day. Urinary glucoprotein,β2-microglobulin, albumin and globulin were detectedby radio-immunoassay.MAIN OUTCOME MEASURES:The changes of urinary proteins of the students before and after administration following maximum exercise and getting-up in next morning.RESULTS: All students involved were good for the trial, without any loss.① The contents of various urinary proteins for the subjects after the maximum exercise or before administration were all obviously increased,and the conditions of natural recovery of proteinuria on getting-up next morning were quiet different: the recovery of urinary albumin was the fattest, basically to the normal;recoveries of β2 micro-globulin and immune-globulin were obvious, but the recovery of glucoprotein was inconsiderable.② After the second trial,in comparing the experimental group with the control group it was found that KSSD can obviously influence the recovery of proteinuria following maximum exercise:The effect in 12 hours did not be shown because of too fast natural recovery of albuminuria. It could promote the recoveries of β2 micro-globulin and immune-globulin. The effect on recovery of urinary of glucoprotein was obvious,basically to the normal for experimental group and basically no change for control group,there was a significant differentiation between the two groups.CONCLUSION:The contents of urinary proteins were obviously increased following maximum loading training, and natural recoveries of the four kinds of proteins presented regulatory changes.KSSD can promote the recovery of proteinuria following maximum exercise to normal volume,suggesting that the medicine has a protecting role to renal function.