建立慢性阻塞性肺疾病动物模型方法的研究进展

慢性阻塞性肺疾病(COPD)是一种重要的慢性呼吸系统疾病,主要包括慢性支气管炎和肺气肿,患病人数多,病死率高,由于其缓慢进行性发展,严重影响患者的劳动能力和生活质量.为此,国内外许多学者近年来对COPD的发病机制进行了大量的研究工作,但是到目前为止,COPD的研究进展仍然十分缓慢,其主要原因是COPD病因太多,发病机制复杂.本文旨在将国内外有关COPD的实验动物模型进行一次总结,并对各种模型的优缺点给予客观的评价.

Progress in Methods to Produce COPD Animal Model

Chronic obstructive pulmonary disease(COPD) is an important chronic respiratory system disease with high morbidity and mortality.It mainly consists of chronic bronchitis and pulmonary emphysema,characterized by slow progressive development.The patients with COPD have weak work ability and poor life quality. Numerous researches both at home and abroad are focused on the potential pathogenesis of COPD in recent years.However,until now the progress in COPD research is still very slow.The main reason for this is not only multiple causes but also complex pathogenesis of COPD.The aim of this review is to sumup the COPD animal models and to objectively evaluate the advantages and disadvantages of each model.