| 类风关1号对佐剂关节炎大鼠滑膜VEGF和COX-2表达的影响 |
| |
| 引用本文： | 张彦,宋欣伟,吴玲燕,康海英,孙伟.类风关1号对佐剂关节炎大鼠滑膜VEGF和COX-2表达的影响[J].天津中医药大学学报,2009,26(3):230-232. |
| |
| 作者姓名： | 张彦 宋欣伟 吴玲燕 康海英 孙伟 |
| |
| 作者单位： | 浙江中医药大学附属第一医院风湿免疫科, 杭州, 310006;浙江中医药大学附属第一医院风湿免疫科, 杭州, 310006;浙江中医药大学附属第一医院风湿免疫科, 杭州, 310006;浙江中医药大学附属第一医院风湿免疫科, 杭州, 310006;浙江中医药大学附属第一医院风湿免疫科, 杭州, 310006 |
| |
| 基金项目： | 浙江省自然科学基金资助项目(205677) |
| |
| 摘 要： | 目的]探讨类风关1号对佐剂关节炎(AA)大鼠滑膜血管内皮细胞生长因子(VEGF)和环氧化酶2(COX-2)表达的影响。方法]建立AA大鼠模型,并给予类风关1号灌胃4周,以免疫组化法检测滑膜组织中VEGF和COX-2的表达。结果]灌胃4周后类风关1号组大鼠膝关节滑膜VEGF和COX-2表达水平明显降低,与AA模型组及雷公藤多苷组相比差异意义有显著性(P<0.01)。结论]类风关1号可明显抑制滑膜组织中VEGF和COX-2的表达,减轻关节病理性血管增生。
|
| 关 键 词： | 类风湿关节炎 大鼠 血管内皮细胞生长因子 环氧化酶 |
| 收稿时间： | 2008/11/20 0:00:00 |
Effects of Rheumatoid Arthritis No.1 on expression of VEGF and COX-2 in synovial membrane in rats with adjuvant arthritis |
| |
| ZHANG Yan,SONG Xin-wei,WU Ling-yan.Effects of Rheumatoid Arthritis No.1 on expression of VEGF and COX-2 in synovial membrane in rats with adjuvant arthritis[J].Journal of Tianjin University of Traditonal Chinese Medicine,2009,26(3):230-232. |
| |
| Authors: | ZHANG Yan SONG Xin-wei WU Ling-yan |
| |
| Institution: | The First Hospital Affiliated to Zhejiang University of TCM, Hangzhou 310006, China;The First Hospital Affiliated to Zhejiang University of TCM, Hangzhou 310006, China;The First Hospital Affiliated to Zhejiang University of TCM, Hangzhou 310006, China;The First Hospital Affiliated to Zhejiang University of TCM, Hangzhou 310006, China;The First Hospital Affiliated to Zhejiang University of TCM, Hangzhou 310006, China |
| |
| Abstract: | Objective] To explore the effects of Rheumatoid Arthritis No. 1 on expression of VEGF and COX-2 in synovial membrane in rats with adjuvant arthritis(AA). Methods] The model of adjuvant arthritis was established in rats. After administration by Rheumatoid Arthritis No. 1,for 4 weeks the immunohistochemical method was used to detect the expression of VEGF and COX-2 in synovial membrane of rats. Results] The expression of VEGF and COX-2 in Rheumatoid Arthritis No. 1 group was significantly decreased compared to the groups of model and tripterygium wilfordii(P<0.01). Conclusion] Rheumatoid Arthritis No.1 can significantly inhibit the expression of VEGF and COX-2 in synovial membrane of rate with adjuvant arthritis,reduce the inflammation of knee joint. |
| |
| Keywords: | rheumatoid arthritis rats VEGF COX-2 |
|
| 点击此处可从《天津中医药大学学报》浏览原始摘要信息 |
| 点击此处可从《天津中医药大学学报》下载免费的PDF全文 |
|
