针药结合治疗持续性躯体形式疼痛障碍的对照研究

目的]研究针刺联合帕罗西汀治疗持续性躯体形式疼痛障碍的疗效。方法]将86例持续性躯体形式疼痛障碍的患者随机分为针刺组(治疗组)、帕罗西汀组(对照组)。在治疗前及治疗2、4、8周末各评定1次简易McGill疼痛量表(SF-MPQ)、汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)和治疗不良反应量表(TESS)。结果]两组间的PPI总分减分率8周末有统计学差异,HAMD和HAMA总分减分率8周末无统计学差异;治疗组HAMD和HAMA总分在4、8周末与治疗前比较,差异有统计学意义(P<0.05,P<0.01);对照组HAMD总分在4、8周末,HAMA总分在2、4、8周末与治疗前比较,差异有统计学意义(P<0.05,P<0.01)。结论]针刺联合帕罗西汀治疗持续性躯体形式疼痛障碍可以更好的缓解疼痛,改善患者不良情绪,且比单独帕罗西汀治疗起效快。

Study of acupuncture combined with paroxetine on durative somatoform pain disorder

Objective] To validate the clinical effect of acupuncture combined with paroxetine in treating durative somatoform pain disorder.Methods] Eighty-six patients with durative somatoform pain disorder were randomly divided into two groups: acupuncture combined with paroxetine group and paroxetine alone group.Before treatment and in the 2,4 and 8 week after treatment,pain,dumps,anxiety and the adverse effects were measured according to SF-MPQ,HAMD,HAMA and TESS standards respectively.Results] In the 8 week after treatment,the differences of the total substrative rate of PPI had statistical significance and the differences of the total substrative rate of HAMD,HAMA had no stratistical significance between these two groups;In the 4 and 8 week after treatment significant differences of the scores of HAMD and HAMA were found when compared with pre-treatment parameters in the treatment group(P<0.05,P<0.01);In the control group,on the days of 4 and 8 week after treatment significant differences of the scores of HAMD were obtained when compared with pre-treatment determinations(P<0.05,P<0.01).Significant differences of HAMA scores in the control group were also found compared with pre-treatment parameters in the 2,4,and 8 week after treatment(P<0.05,P<0.01).Conclusion] Acupuncture combined with paroxetine is effective in the treatment of durative somatoform pain disorder.