| 新斯的明乳膏体外透皮吸收实验研究 |
| |
| 引用本文： | 赵维娟,许景峰,边佳明.新斯的明乳膏体外透皮吸收实验研究[J].中国药房,2003,14(6):335-336. |
| |
| 作者姓名： | 赵维娟 许景峰 边佳明 |
| |
| 作者单位： | 北京军区总医院药理科,北京市,100700 |
| |
| 摘 要： | 目的 :考察新斯的明乳膏的体外透皮吸收效果。方法 :采用小鼠离体皮肤作为渗透屏障 ,研究不同浓度氮酮对新斯的明渗透作用的影响。结果 :氮酮可明显提高新斯的明对皮肤的渗透作用 ,含2%和5%氮酮的新斯的明乳膏累积释放总量比空白乳膏分别增加了7 17 %和11 87%。结论 :新斯的明乳膏具有良好的皮肤渗透性 ,5%氮酮对其促渗效果最好
|
| 关 键 词： | 新斯的明 氮酮 透皮吸收 |
| 文章编号： | 1001-0408(2003)06-0335-02 |
| 修稿时间： | 2002年5月10日 |
Experimental Study of Percutaneous Absorption of Neostigmine Cream in Vitro |
| |
| ZHAO Weijuan,XU Jingfeng,BIAN Jiaming.Experimental Study of Percutaneous Absorption of Neostigmine Cream in Vitro[J].China Pharmacy,2003,14(6):335-336. |
| |
| Authors: | ZHAO Weijuan XU Jingfeng BIAN Jiaming |
| |
| Abstract: | OBJECTIVE:To study the in vitro percutaneous absorption of neostigmine cream.METHODS:Using isolated mouse skin as permeation barrier,the influence of different concentrations of azone on percutaneous permeation of neostigmine was studied.RESULTS:Azone could obviously enhance the percutaneous permeation of neostigmine,and the accumulative permeation quantity of neostigmine cream containing2%and5%azone increased7.17%and11.87%respectively compared with that of cream without azone.CONCLUSION:The percutaneous permeability of neostigmine cream is satisfactory and the best concentration of azone in enhancing permeation seems to be5%. |
| |
| Keywords: | neostigmine azone percutaneous absorption |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
