组织工程中药物控制释放技术的应用研究

目的 研究应用药物控制释放技术，在组织工程中实现对生长因子的活性保护和控制释放。方法 应用药物控制释放技术，采用生物降解高分子对药物进行包埋或微包囊。结果 用脂肪族聚内酯为各类药物，包括生物活性物质的药物载体，通过调节脂肪族聚内酯的分子结构和控制释放方法，在采用聚丙交酯为神经导管和对生长因子实行包埋后，成功地实现了对大鼠坐骨神经5、10、15和20mm缺损的修复。结论 可利用脂肪族聚内酯作为药物载体，保护各类生长因子的生物活性，并实现对它们的持续释放。

RESEARCH AND APPLICATION OF DRUG CONTROLLED RELEASE TECHNIQUE IN TISSUE ENGINEERING

Objective To investigate protection of biological activity and controlled release of growth factor by means of drug controlled release technique in tissue engineering. Methods Using drug controlled release technique that to embed or microcapsulate the biological drug with biodegradable polymer. Results The aliphatic polylactone could be used as drug carrier for each drug including the biological matter. And the release behavior of the drug could be controlled by adjusting the molecular structure of the carrier and the controlled release method. The successful example, that to realize regeneration of rat's sciatic nerve with 5,10, 15 and 20 mm of gap by using polylactide as nerve guide and the embedding growth factor, had been obtained. Conclusion It is possible to realize protection of biological activity and sustained release of growth factor by using aliphatic polylactone as drug carrier.