S—腺苷蛋氨酸治疗抑郁症

目的：观察新型天然抗抑郁药Ｓ－腺苷蛋氨酸的抗抑郁作用及其不良反应。方法：采用该药开放性治疗各种抑郁性障碍３１例。采用Ｈａｍｉｌｔｏｎ抑郁量表和临床总体印象评定临床疗效。结果：全部病人（包括脱落病人）的有效率为７２．４％。疗程分析发现该药起效较快，在治疗第四天量表评分业已有显著下降。第二周时已较基线分下降了５２％。因子分析发现，该药对主观焦虑因子效果不佳，对其它各因子均有显著效果。该药不良反应轻微，无一例因药物不良反应导致治疗中断。结论：Ｓ－腺苷蛋氨酸是一种安全有效的天然抗抑郁药物

Ademetionine in the Treatment of Depressive Disorders

The study aimed to investigate the antidepressive efficacy and safety of a natural substance existed in living organs,S adenosyl l methionine.Thirty one patients with various depressive disorders were disorders treated with the drug.Hamilton Rating Scale of Depression (HRSD) and Clinical Global Impression (CGI)were used to evaluate the clinical response.Among all the enrolled patients,72 4% were improved according to CGI as well as HRSD score.Its antidepressive effect appeared earlier for the HRSD scores,which decreased significantly at day 4 and down to 48% at day 14.Factor analysis indicated that the drug had slight therapeutic effect on the subjective anxiety while other factors showed significant changes during the treatment.Few adverse effects were found during the trial We concluded that ademetionine is a new effective and safe antidepressant with earlier therapeutic onset of action.