VAMP-8 gene variant is associated with increased risk of early myocardial infarction |
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Authors: | Jaros?aw Gor?cy Iwona Gor?cy Mariusz Kaczmarczyk Mi?osz Parczewski Lech Cyry?owski Miros?aw Brykczyński Ma?gorzata Peregud-Pogorzelska Andrzej Ciechanowicz |
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Affiliation: | 1.Department of Cardiology, Pomeranian Medical University, Szczecin, Poland;2.Department of Laboratory Diagnostics and Molecular Medicine, Pomeranian Medical University, Szczecin, Poland;3.Department of Infectious Diseases and Hepatology, Pomeranian Medical University, Szczecin, Poland;4.CT and MRI Clinic, Non-public Health Care Clinic "Our Doctor", Szczecin, Poland;5.Department of Cardiosurgery, Pomeranian Medical University, Szczecin, Poland |
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Abstract: | IntroductionSingle nucleotide polymorphism in the 3’ untranslated region of the vesicle-associated membrane protein gene (VAMP-8) has been associated with increased risk of early-onset myocardial infarction (MI). In this study the risk of early onset MI conferred by VAMP-8 gene polymorphism was investigated in a group of 171 male subjects.Material and methodsMale patients with a history of MI who underwent coronary angiography were enrolled and divided into early (incident < 55 years of age) and late (incident ≥ 55 years of age) MI onset groups. Apart from the RFLP-PCR based analysis of the VAMP-8 variant, history of hypertension, lipid abnormalities, smoking and body mass index were recorded. In statistical analyses odds ratios and relative risk were used as a measure of genotype-MI association while logistic regression was implemented for evaluation of MI risk factor strength.ResultsVAMP-8 A allele frequency proved to be significantly higher in the early-onset MI group and conferred higher relative risk of early MI in the investigated cohort, when calculated for the individual A allele (p = 0.029). In logistic regression analyses no association between risk genotypes and traditional risk factors was observed.ConclusionsIn this study VAMP-8 A variant was identified as a risk allele for early MI in male subjects. |
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Keywords: | myocardial infarction VAMP-8 gene polymorphism risk factor |
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