| 孔蛋白对蜱虫及其相关病原体的作用 |
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| 引用本文： | 郑卫青. 孔蛋白对蜱虫及其相关病原体的作用[J]. 中华卫生杀虫药械, 2021, 0(2): 170-175 |
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| 作者姓名： | 郑卫青 |
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| 作者单位： | 传染病预防控制国家重点实验室研究基地、江西省动物源与媒介生物性传染病重点实验室、南昌市疾病预防控制中心 |
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| 基金项目： | 江西省科技厅项目(编号:20192BBHL80013、20161BBG70005);江西省卫计委项目(编号:20162007);南昌市科技局项目(编号:洪科字[2016]96号第77项)。 |
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| 摘 要： | 蜱虫能携带很多病原体,在畜牧生产和公共卫生上具有十分重要的意义.研究蜱虫与病原体的相互关系,有助于开发、研究防蜱控病的药物、疫苗.孔蛋白存在于大量生物体中,也包括蜱虫.它穿梭于线粒体膜,形成膜通道,通过阴阳离子调节电压开闭通道,进而控制细胞代谢过程中的物质和能量流.本文阐述了孔蛋白的结构、进化关系和功能,并重点概述了蜱...
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| 关 键 词： | 蜱虫 孔蛋白 病原体 控制 |
The possible roles of porin in ticks and pathogen infection |
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| ZHENG Wei-qing. The possible roles of porin in ticks and pathogen infection[J]. Chinese Journal of Hygienic Insecticides and Equipments, 2021, 0(2): 170-175 |
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| Authors: | ZHENG Wei-qing |
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| Affiliation: | (The Collaboration Unit for Field Epidemiology of State Key Laboratory for Infectious Disease Prevention and Control,Jiangxi Provincial Key Laboratory of Animal-origin and Vector-borne Diseases,Nanchang Center for Disease Control and Prevention,Nanchang 330000,China) |
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| Abstract: | Ticks, transmitting numerous pathogens, bring major negative impacts on domestic animal production and public health.Elucidation of interaction between ticks and pathogens greatly contributes to the development of anti-tick-and-pathogen vaccines and drugs.Voltage dependent anion channel protein(VDAC),also called as mitochondrial porin, is present in wide range of organisms, including ticks.Porin is expressed on mitochondrial membrane and helps to mediate flux of materials and energy between inside and outside mitochondria.The structure, systematic evolution and biological function of porin, and physiological function and effects on pathogen transmission in ticks were reviewed in the article.Limitations in tick porin research and its effects on pathogen transmission, and the necessary work on the role of the porin in tick blood feeding and pathogen transmission in the future were discussed and delineated. |
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| Keywords: | ticks porin pathogen control |
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