Doxorubicin-loaded solid lipid nanoparticles to overcome multidrug resistance in cancer therapy |
| |
| Authors: | Keon Wook Kang Myung-Kwan Chun Ok Kim Robhash Kusam Subedi Sang-Gun Ahn Jung-Hoon Yoon Hoo-Kyun Choi |
| |
| Institution: | 1. BK21 Project Team, College of Pharmacy, Chosun University, Gwangju, South Korea;2. Department of Pathology, College of Dentistry, Chosun University, Gwangju, South Korea;3. Research Center for Resistant Cells, Chosun University, Gwangju, South Korea |
| |
| Abstract: | In the present study we developed doxorubicin-loaded solid lipid nanoparticles (SLN-Dox) using biocompatible compounds, assessed the in vitro hemolytic effect, and examined their in vivo effects on drug retention and apoptosis intensity in P-glycoprotein-overexpressing MCF-7/ADR cells, a representative Dox-resistant breast cancer cell line. Our SLNs did not show hemolytic activity in human erythrocytes. In comparison with Dox, SLN-Dox efficiently enhanced apoptotic cell death through the higher accumulation of Dox in MCF-7/ADR cells. Therefore, SLN-Dox have potential to serve as a useful therapeutic approach to overcome the chemoresistance of adriamycin-resistant breast cancer.From the Clinical EditorDoxorubicin loaded solid lipid nanoparticles (SLN-Dox) were studied in a cell line representative of doxorubicin resistant breast cancer. The nanoparticles did not show hemolytic activity; furthermore, they efficiently enhanced apoptotic cell death through higher accumulation of doxorubicin in cancer cells. This approach may be viable in overcoming the chemoresistance of adriamycin resistant breast cancer. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
