| 人诱导多能干细胞分化来源心肌细胞特征及促成熟方法研究进展 |
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| 引用本文： | 刘明璐(综述),王伟,付炜(审校). 人诱导多能干细胞分化来源心肌细胞特征及促成熟方法研究进展[J]. 组织工程与重建外科, 2021, 0(2): 154-158 |
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| 作者姓名： | 刘明璐(综述) 王伟 付炜(审校) |
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| 作者单位： | 上海交通大学医学院附属上海儿童医学中心心胸外科;上海交通大学医学院附属上海儿童医学中心儿科转化医学研究所;上海市组织工程研究重点实验室 |
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| 基金项目： | 国家自然科学基金(81670372);上海市浦江人才计划(18PJD031);上海交通大学医学院转化医学协同创新中心合作研究项目(TM201821);上海市组织工程重点实验室开放课题。 |
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| 摘 要： | 人诱导多能干细胞分化来源的心肌细胞(Human induced pluripotent stem cells-derived cardiomyocytes,hiPSC-CMs)为心脏修复、心脏药物测试、体外心脏建模等提供了理想细胞来源.但hiPSC-CMs与心肌细胞相比并不成熟,表现在缺乏某些特定基因表达,结构、代谢、...
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| 关 键 词： | 人诱导多能干细胞 心肌细胞 成熟 |
Research progress of characteristics and maturation methods of human induced pluripotent stem cells-derived cardiomyocytes |
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| Affiliation: | (Department of Pediatric Cardiothoracic Surgery;Institute of Pediatric Translational Medicine,Shanghai Children's Medical Center,Shanghai Jiao Tong University School of Medicine,Shanghai 200127,China;Shanghai Key Laboratory of Tissue Engineering,Shanghai 200011,China) |
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| Abstract: | The human induced pluripotent stem cells-derived cardiomyocytes(hiPSC-CMs)provide an ideal cell source for heart repair,cardiac drug testing,in vitro cardiac modeling,etc.However,hiPSC-CMs is less mature than cardiomyocytes,showing a lack of certain gene expression,structural,metabolic,electrophysiological immaturity,and low level of Ca 2+treatment.Many methods including biochemical stimulation,physical stimulation,co-culture,3D culture and miRNA are devoted to promoting hiPSC-CMs maturation.In this paper,the characteristics and maturation methods of hiPSC-CMs were reviewed,and the development direction of this field was put forward. |
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| Keywords: | Human induced pluripotent stem cells-derived cardiomyocytes Cardiomyocytes Maturation |
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