Ki-67、p53和VEGF在鼻咽癌组织中的表达及临床意义

目的探讨Ki-67、p53和VEGF在鼻咽癌组织中的表达及其临床意义。方法选择2015年1月至2020年7月在我院初诊的鼻咽癌患者90例为观察组,选择同期50例在我院就诊的鼻咽黏膜慢性炎症患者为对照组。通过免疫组化检测两组鼻咽组织中Ki-67、p53和VEGF的表达,并探讨三个免疫组化指标与临床病理特征之间的关系。结果(1)鼻咽癌组织中Ki-67、p53、VEGF阳性表达均明显高于鼻咽部炎症组(P<0.05)。(2)鼻咽癌组织中Ki-67、p53、VEGF阳性表达与患者的性别、年龄等病理因素没有相关性(P>0.05),与病理分型、颈部淋巴结转移以及临床分期具有密切相关性(P<0.05)。(3)Ki-67、p53、VEGF三者在鼻咽癌组织中的表达相互之间均呈正相关(P<0.05)。结论Ki-67、p53和VEGF与鼻咽癌的发生和发展有密切相关性,三者的检测对鼻咽癌的诊断及治疗具有重要的参考价值。

Expressions and clinical significance of Ki-67,P53 and VEGF in nasopharyngeal carcinoma

Objective To investigate the expressions of Ki-67,P53 and VEGF and their clinical significances in nasopharyngeal carcinoma.Methods 90 patients with nasopharyngeal carcinoma newly diagnosed in our hospital from January 2015 to July 2020 were selected as the observation group.50 patients with chronic nasopharyngeal mucosa inflammation in our hospital were selected as the control group.And then,immunohistochemistry was used to detect the expressions of Ki-67,p53 and VEGF in nasopharyngeal tissues of the two groups,and relationship between these immunohistochemical parameters and clinicopathological features was explored.Results(1)The positive expressions of Ki-67,P53 and VEGF in nasopharyngeal carcinoma tissues were significantly higher than those in the nasopharyngeal inflammation group(P<0.05).(2)The positive expression of Ki-67,P53 and VEGF in nasopharyngeal carcinoma tissues was not correlated with the patient’s gender,age and other pathological factors(P>0.05),but was closely correlated with pathological typing,cervical lymph node metastasis and clinical stage(P<0.05).(3)Ki-67,P53 and VEGF were positively correlated in nasopharyngeal carcinoma tissues(P<0.05).Conclusion Ki-67,P53 and VEGF are closely related to the occurrence and development of nasopharyngeal carcinoma,and the detection of the three has important reference value for the diagnosis and treatment of nasopharyngeal carcinoma.