| 配对免疫球蛋白样受体B在认知功能障碍发生机制中作用的研究进展 |
| |
| 引用本文： | 徐巧精,田毅,胡乃元,赵祥坤. 配对免疫球蛋白样受体B在认知功能障碍发生机制中作用的研究进展[J]. 国际麻醉学与复苏杂志, 2021, 42(3): 321-324 |
| |
| 作者姓名： | 徐巧精 田毅 胡乃元 赵祥坤 |
| |
| 作者单位： | 中南大学湘雅医学院附属海口医院麻醉科 570208 |
| |
| 基金项目： | 国家自然科学基金(81660195);海南省国际科技合作专项(KJHZ2014-20);海南省卫生健康行业科研立项(20A200157)。 |
| |
| 摘 要： | 配对免疫球蛋白样受体B（paired immunoglobulin like receptor B, PirB）调节突触可塑性作用被认为是造成认知功能障碍的重要原因之一，在中枢神经系统中，过表达的PirB通过增加神经元的凋亡来抑制神经元的存活。文章探讨了PirB抑制中枢神经损伤后轴突生长的机制，分析了PirB在神经退行...
|
| 关 键 词： | 认知功能 配对免疫球蛋白样受体B 信号通路 |
Research advances in the role of paired immunoglobulin like receptor B in the pathogenesis of cognitive dysfunction |
| |
| Xu Qiaojing,Tian Yi,Hu Naiyuan,Zhao Xiangkun. Research advances in the role of paired immunoglobulin like receptor B in the pathogenesis of cognitive dysfunction[J]. international journal of anesthesiology and resuscitation, 2021, 42(3): 321-324 |
| |
| Authors: | Xu Qiaojing Tian Yi Hu Naiyuan Zhao Xiangkun |
| |
| Affiliation: | (Department of Anesthesiology,Central South University Xiangya School of Medicine Affiliated Haikou Hospital,Haikou 570208,China) |
| |
| Abstract: | Regulating synaptic plasticity by paired immunoglobulin like receptor B(PirB)is considered to be one of the essential causes of cognitive dysfunction.In the central nervous system,overexpression of PirB can cause death of neurons by increasing apoptosis of neurons.This review aims to discuss the mechanism of PirB in inhibiting axonal growth after central nervous system injury and to elucidate the essential pathogenic role of PirB in neurodegenerative diseases,traumatic brain injury and stroke,and other cognitive function-related diseases.By regulating selective blocking of PirB function,people can intervene the cognitive dysfunction caused by PirB related pathways. |
| |
| Keywords: | Cognitive function Paired immunoglobulin like receptor B Signaling pathway |
| 本文献已被 维普 万方数据 等数据库收录！ |
