布托啡诺联合右美托咪定在重症疾病患者镇痛镇静中的疗效分析

目的研究布托啡诺联合右美托咪定在重症疾病患者镇痛镇静中的疗效。方法90例重症疾病患者,根据用药不同分为常规组及研究组,每组45例。常规组患者采用咪达唑仑与布托啡诺进行镇痛镇静治疗,研究组患者采用布托啡诺联合右美托咪定进行镇痛镇静治疗。比较两组患者Ramsay镇静评分、行为疼痛量表(BPS)评分、匹兹堡睡眠质量指数(PSQI)评分及生命体征指标。结果研究组Ramsay镇静评分(4.96±0.21)分、BPS评分(7.84±1.15)分高于常规组的(3.26±0.48)、(5.45±1.62)分,PSQI评分(2.21±0.43)分低于常规组的(6.39±1.57)分,差异有统计学意义(P<0.05)。治疗后,研究组患者的心率、呼吸频率、收缩压、舒张压均低于常规组,差异有统计学意义(P<0.05)。结论将布托啡诺与右美托咪定联合,对重症疾病患者进行镇痛镇静治疗,用药后可以有效避免患者生命体征波动,缓解患者疼痛感受,提高睡眠质量,减少疾病影响,临床疗效显著。

Efficacy analysis of butorphanol combined with dexmedetomidine in analgesia and sedation of patients with severe disease

Objective To study the efficacy of butorphanol combined with dexmedetomidine in analgesia and sedation of critically ill patients.Methods A total of 90 patients with severe disease were randomly divided into conventional group and research group,with 45 cases in each group.The conventional group received midazolam and butorphanol for analgesia and sedation,and the research group received butorphanol and dexmedetomidine for analgesia and sedation.The Ramsay score,behavior pain scale(BPS)score,Pittsburgh sleep quality index(PSQI)score and vital signs were compared between the two groups.Results The Ramsay score(4.96±0.21)points,BPS score(7.84±1.15)points of the research group were higher than(3.26±0.48)and(5.45±1.62)of the conventional group,and PSQI score(2.21±0.43)points was lower than(6.39±1.57)points of the conventional group,and the difference was statistically significant(P<0.05).After treatment,the heart rate,respiratory rate,systolic blood pressure and diastolic blood pressure of the research group were lower than those of the conventional group,and the difference was statistically significant(P<0.05).Conclusion Combining butorphanol and dexmedetomidine for analgesia and sedation shows remarkable efficacy for patients with severe disease,and it can effectively avoid fluctuations in the patient’s vital signs,relieve pain,improve sleep quality,and reduce the impact of the disease.