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Circulating Tumor Cells in the Management of Breast Cancer
Authors:Govardhanan Nagaiah  Jame Abraham
Affiliation:1. German Heart Center Munich, Technische Universität München, Munich, Germany;2. DZHK (German Center for Cardiovascular Research), and partner site Munich Heart Alliance, Munich, Germany;3. Department of Cardiac Surgery, Vienna General Hospital, Medical University of Vienna, Vienna, Austria;4. Department of Cardiovascular Surgery, Justus-Liebig University Gießen, Germany;5. Department of Cardiac Surgery, Klinikum Links der Weser, Bremen, Germany;6. Department of Cardiology and Angiology, Klinikum Links der Weser, Bremen, Germany;7. Department of Thoracic and Cardiovascular Surgery, Georg-August-University Goettingen, Goettingen, Germany;8. Department of Cardiac Surgery, Paracelsus Medical University, Klinikum Nürnberg, Germany;9. Department of Cardiac Surgery, Asklepios Klinik St. Georg/Cardioclinic Harburg, Hamburg, Germany;10. Institute of Physiology, Justus-Liebig University, Giessen, Germany;11. Department of Cardiac Surgery, Kerckhoff Heart and Thorax Center, Bad Nauheim, Germany;12. Department of Cardiothoracic and Vascular Surgery, German Heart Institute Berlin, Germany;13. DZHK (German Center for Cardiovascular research)-partner side Berlin;14. Department of Cardiovascular Surgery, Heart Center Freiburg University, Freiburg, Germany;15. Department of Cardiovascular Surgery, University Hospital Schleswig-Holstein, Kiel, Germany.;p. Department of Cardiac Surgery, Heart Center Leipzig, University of Leipzig, Leipzig, Germany;q. Department of Cardiac and Thoracic Vascular Surgery, University of Lübeck, Lübeck, Germany;r. Medical Clinic II, Cardiology, Angiology and Intensive Care Medicine, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany;s. Department of Cardiology, Kerckhoff Heart and Thorax Center, Germany Justus Liebig University of Giessen, Department of Internal Medicine I, Gießen, Germany;t. Department of Cardiology, Heart Center Ludwigshafen, Ludwigshafen am Rhein, Germany;u. Klinik für Innere Medizin, Schön Klinik Neustadt, Neustadt i.H., Germany;v. Department of Cardiovascular Surgery, German Heart Center Munich, Germany.;1. College of Medicine, China Medical University Hospital, Taichung, Taiwan;2. Department of Family Medicine, China Medical University Hospital, Taichung, Taiwan;3. Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan;4. Graduate Institute of Integrated Medicine, China Medical University, Taichung, Taiwan;5. Department of Internal Medicine, Taichung Tzu Chi General Hospital, Taichung, Taiwan
Abstract:Most deaths from breast cancer are from metastatic disease. Tests that predict an individual's risk of developing metastatic disease could be useful. There is growing evidence that circulating tumor cells (CTC) could help predict recurrence and effectiveness of therapy. However, there are unresolved issues with CTC detection methods and their implementation in the community. The utility of CTC testing in the management of breast cancer is unclear based on current studies. This article reviews the role of CTC testing in the management of early and metastatic breast cancer.
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