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Frontal lobe epilepsy may present as myoclonic seizures
Authors:Yong Won Cho  Sang Doe Yi  Gholam K. Motamedi
Affiliation:1. Child Neuropsychiatry Unit, Department of Neuroscience, University-Hospital of Parma, Via Gramsci 14, Parma, Italy;2. Department of Life and Reproduction Sciences, University of Verona, P.le Scuro 10, Verona, Italy;3. Department of Biomedical Sciences, Metabolism and Neuroscience, University of Modena and Reggio Emilia, Nuovo Ospedale Civile Sant''Agostino Estense, Via Giardini 1355, Modena, Italy;4. Centro Avanzado de Epilepsia, Clinica Las Condes, Lo Fontecilla 441, Las Condes, Santiago, Chile;5. Department of Neurological Sciences, University of Bologna, Via Foscolo 7, Bologna, Italy;6. Department of Neuroscience, University of Parma, Via Volturno 39/E, Parma, Italy
Abstract:We describe a patient with seizures arising from right anterior–inferior frontal lobe presenting as myoclonic epilepsy. A 19-year-old man had experienced frequent paroxysmal bilateral myoclonic jerks involving his upper arms, shoulders, neck, and upper trunk since the age of 10. His baseline EEG showed intermittent right frontal spikes, and his ictal EEG showed rhythmic sharp theta discharges in the same area. MRI revealed cortical dysplasia in the right inferior frontal gyrus, and ictal–interictal SPECT analysis by SPM showed increased signal abnormality in this region. Diffusion tensor imaging (DTI) showed defects in fasciculi in the same area. These findings suggest that frontal lobe epilepsy should be considered in some patients with myoclonic seizures.
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