伊立替康载药微球肝动脉栓塞治疗不可手术切除的结直肠癌肝转移的效果分析

目的分析伊立替康载药微球肝动脉栓塞治疗不可手术切除的结直肠癌肝转移的临床效果。方法50例不可手术切除的结直肠癌肝转移患者,随机分为实验组和对照组,各25例。实验组采用伊立替康载药微球肝动脉栓塞治疗,对照组采用全身化疗。分析比较两组患者的近期疗效、生存情况及并发症发生情况。结果实验组患者完全缓解(CR)率、部分缓解(PR)率、疾病稳定(SD)率、疾病进展(PD)率、客观缓解率(ORR)和疾病控制率(DCR)分别为4.0%、56.0%、20.0%、20.0%、60.0%、80.0%;对照组患者的CR率、PR率、SD率、PD率、ORR和DCR分别为0、16.0%、40.0%、44.0%、16.0%、56.0%;实验组ORR显著高于对照组,差异具有统计学意义(P<0.05);两组DCR比较差异无统计学意义(P>0.05)。两组患者1、2年生存率比较差异无统计学意义(P>0.05);实验组患者3年生存率高于对照组,差异有统计学意义(P<0.05)。实验组患者贫血、血小板降低、呕吐、乏力和肝功能异常发生率均显著低于对照组,差异具有统计学意义(P<0.05);两组患者白细胞减少、恶心、疼痛和腹泻发生率比较差异无统计学意义(P>0.05)。结论伊立替康载药微球肝动脉栓塞治疗不可手术切除的结直肠癌肝转移的临床效果较全身化疗显著,其不良反应相对较少,临床可推广使用。

Effect analysis of trans-arterial chemoembolization with irinotecan drug-eluting beads in the treatment of unresectable liver metastasis of colorectal cancer

Objective To analyze the clinical effect of trans-arterial chemoembolization with irinotecan drug-eluting beads in the treatment of unresectable liver metastasis of colorectal cancer.methods A total of 50 patients with unresectable liver metastasis of colorectal cancer were randomly divided into experimental group and control group,with 25 cases in each group.The experimental group was treated with trans-arterial chemoembolization with irinotecan drug-eluting beads,and the control group was treated with systemic chemotherapy.The short-term efficacy,survival status and occurrence of complications were analyzed compared between the two groups.Results The complete remission(CR)rate,partial remission(PR)rate,stable disease(SD)rate,progressive disease(PD),objective remission rate(ORR),disease control rate(DCR)of the experimental group were 4.0%,56.0%,20.0%,20.0%,60.0%and 80.0%,which were 0,16.0%,40.0%,44.0%,16.0%and 56.0%of the control group.The ORR of the experimental group was significantly higher than that of the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in DCR between the two groups(P>0.05).There was no statistically significant difference in 1 and 2 year survival rte bewteen the two groups(P>0.05).The 3 year survival rate of the experimental group was higher than that of the control group,and the difference was statistically significant(P<0.05).The incidence of anemia,thrombocytopenia,vomiting,fatigue and abnormal liver function of the experimental group were significantly lower than those of the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in incidence of leucopenia,nausea,pain and diarrhea between the two groups(P>0.05).Conclusion Trans-arterial chemoembolization with irinotecan drug-eluting beads shows more significant clinical effect than systemic chemotherapy in the treatment of unresectable liver metastasis of colorectal cancer with less adverse reactions.It can be promoted and applied in the clinic.