| sigma-1受体在缺血性脑卒中的作用及机制研究进展 |
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| 引用本文： | 张慧敏,王志萍. sigma-1受体在缺血性脑卒中的作用及机制研究进展[J]. 国际麻醉学与复苏杂志, 2021, 42(3): 334-336,I0007 |
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| 作者姓名： | 张慧敏 王志萍 |
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| 作者单位： | 南京医科大学附属无锡市人民医院麻醉科 214023;徐州医科大学附属医院麻醉科 221002 |
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| 摘 要： | 缺血性脑卒中(ischemic stroke, IS)是最常见的神经系统疾病,因其高致残率和病死率,且治疗时间窗口窄,迫切需要寻找新的治疗手段来减少IS后的脑损伤。sigma-1受体(sigma-1 receptor, Sig-1R)是一种特异性分子伴侣蛋白,在中枢神经系统中高表达,参与神经元可塑性调节。文章通过对Sig-1R结构、分布、相关通路及配体的阐述,针对Sig-1R在IS中的作用及其机制进行综述,为探索Sig-1R相关配体发展为抗IS候选药物提供理论依据。
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| 关 键 词： | Sigma-1受体 缺血性脑卒中 配体 |
Research progress on the role and mechanism of sigma-1 receptor in ischemic stroke |
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| Zhang Huimin,Wang Zhiping. Research progress on the role and mechanism of sigma-1 receptor in ischemic stroke[J]. international journal of anesthesiology and resuscitation, 2021, 42(3): 334-336,I0007 |
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| Authors: | Zhang Huimin Wang Zhiping |
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| Affiliation: | (Department of Anesthesiology,Wuxi People's Hospital Affiliated to Nanjing Medical University,Wuxi 214043,China;Department of Anesthesiology,the Affiliated Hospital of Xuzhou Medical University,Xuzhou 221002,China) |
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| Abstract: | Ischemic stroke(IS)is the most common neurological disease.With respect to its high disability and mortality and narrow treatment time window,there is an urgent need to find new treatment methods to reduce brain damage after IS.Sigma-1 receptor(Sig-1R)is a specific molecular chaperone protein that is highly expressed in the central nervous system and participates in the regulation of neuronal plasticity.This paper introduced the structure,distribution,related pathways and ligands of Sig-1R,and summarized the role and mechanism of Sig-1R in IS,so as to provide theoretical evidence for exploring the development of Sig-1R-related ligands as anti-IS drug candidates. |
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| Keywords: | Sigma-1 receptor Ischemic stroke Ligands |
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