| 安胃丸对小鼠幽门螺杆菌感染性胃炎的治疗作用 |
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| 引用本文： | 任守忠,郭建生,曾贵荣,伍参荣,李鑫.安胃丸对小鼠幽门螺杆菌感染性胃炎的治疗作用[J].中国医院药学杂志,2012(2):117-120. |
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| 作者姓名： | 任守忠 郭建生 曾贵荣 伍参荣 李鑫 |
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| 作者单位： | 海南医学院药学院;湖南中医药大学中药现代化重点实验室;湖南省药物安全评价研究中心;湖南中医药大学微生物教研室 |
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| 摘 要： | 目的:观察安胃丸对幽门螺杆菌相关性胃炎的防治作用。方法:用幽门螺杆菌菌液给小鼠灌胃制备幽门螺杆菌感染性胃炎模型。给药20 d后,取胃窦部组织进行快速尿素酶实验、细菌培养及Gimsa染色进行HP的检测,并进行HE染色观察小鼠胃黏膜组织损伤情况。结果:安胃丸高、中、低剂量组的幽门螺杆菌根除率分别为70%,60%,30%,同时胃窦部黏膜炎症也有明显改善。结论:安胃丸对幽门螺杆菌相关性胃炎有一定防疗作用。
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| 关 键 词： | 安胃丸 幽门螺杆菌 胃炎 |
Preventive and therapeutic effects of Anwei pills on the H. pylori infected gastritis in the Balb/c mice model |
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| REN Shou-zhong,GUO Jian-sheng,ZENG Gui-rong,WU Shen-rong,LI Xin.Preventive and therapeutic effects of Anwei pills on the H. pylori infected gastritis in the Balb/c mice model[J].Chinese Journal of Hospital Pharmacy,2012(2):117-120. |
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| Authors: | REN Shou-zhong GUO Jian-sheng ZENG Gui-rong WU Shen-rong LI Xin |
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| Institution: | 1.School of pharmacy,Hainan Medical Univerisity,Hainan Haikou 571101,China;2.Key Laboratory of Traditional Chinese Medicine Modernization,Hunan Medical University,Hunan Changsha 410208,China;3.Huan Provincial Center of Safety Evaluation of Medicine,Hunan Changsha 410031,China;4.Department of Microorganism,Hunan Medical University,Hunan Changsha 410208,China) |
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| Abstract: | OBJECTIVE To observe the preventive and therapeutic effects of Anwei pills on H.pylori infected gastritis in the Balb/c mice.METHODS A Balb/c mouse model with Hp infectious gastritis was established through oral administration of mankind Hp,after oral administration of Anwei pills for 20 day,the stomach was removed from each mouse for the rapid urea assay,H.pylori cultivation and Gimsa staining,pathologic changes of the gastric mucosa were studied by microscope.RESULTS The Hp eradicate rate in Anwei pills high,middle,low groups were 70%、60%、30% respectively.In the same way,the chronic inflammation of the mice gastric mucosa was also reduced significantly.CONCLUSION Anwei pill had the preventive and effects on the H.pylori infected gastritis in the Balb/c mice model. |
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| Keywords: | Anwei pills Helicobacter pylori gastritis |
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