Risk factors for central neck lymph node metastasis of clinically noninvasive,node-negative papillary thyroid microcarcinoma |
| |
Authors: | Joon Pyo Park Jong-Lyel Roh Jeong Hyun Lee Jung Hwan Baek Gyungyub Gong Kyung-Ja Cho Seung-Ho Choi Soon Yuhl Nam Sang Yoon Kim |
| |
Institution: | 1. Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 138-736, Republic of Korea;2. Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 138-736, Republic of Korea;3. Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 138-736, Republic of Korea;4. Biomedical Research Institute, Korea Institute of Science and Technology, Seoul, Republic of Korea |
| |
Abstract: | BackgroundTo examine predictive factors for subclinical central neck lymph node metastases (LNM) of papillary thyroid microcarcinoma (PTMC).MethodsThe clinical and pathological findings of 287 patients with clinically noninvasive, node-negative, solitary papillary thyroid carcinoma (PTC), who had undergone thyroidectomy plus central compartment neck dissection and showed pathologically confirmed nodal metastases, were analyzed. Predictive risk factors for central LNM were quantified.ResultsPathologic LNM was identified in 63 (32.6%) PTMC patients and 48 (51.0%) PTC patients (tumor size >1 cm; P = .003). Tumor size (>.7 cm; P = .011), multifocality (P = .010), and microscopic extracapsular extension (P = .050) were significant variables predictive of central LNM from PTMC in univariate analysis. Tumor size (odds ratio 2.28, 95% confidence interval 1.19 to 4.38; P = .014) and multifocality (odds ratio 2.38, 95% confidence interval 1.14 to 4.93; P = .020) were independent variables predictive of central LNM in multivariate analysis.ConclusionsCervical LNM is highly prevalent in clinically noninvasive, node-negative PTC. Central neck LNM is associated with larger tumor size and multifocality of PTMC. |
| |
Keywords: | Papillary thyroid carcinoma Subclinical lymph node metastasis Central neck Lymph node dissection Predictive factors |
本文献已被 ScienceDirect 等数据库收录! |
|