The effects of exogenous melatonin on the morphology of thyrocytes in pinealectomized and irradiated rats |
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Authors: | Z Kundurovic E Sofic |
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Institution: | (1) Faculty of Medicine, Department of Histology and Embryology, University of Sarajevo, Bosnia and Herzegovina;(2) Faculty of Science, Department of Chemistry, University of Sarajevo, Bosnia and Herzegovina |
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Abstract: | Summary. We investigated the effects of exogenous melatonin on the thyrocytes morphology in gamma-irradiated rats under condition where
the pineal gland, as a main physiological source of endogenous melatonin, was removed. Three months after pinealectomy animals
were divided into two groups: one group of animals was treated with 0.5 ml of vehicle (ethanol diluted in water) and other
group was injected intraperitoneally 2 mg/kg of melatonin dissolved in 0.5 ml of vehicle daily during the period of fourteen
days. After this treatment all the animals were irradiated with a single dose of 8 Gy gamma rays. Ionising radiation induced
apoptosis, hydropic swelling or/and necrosis in both groups of animals, however these changes were less discerned in the thyrocytes
of melatonin-treated animals. Our findings demonstrate that administration of exogenous melatonin prior to irradiation reduces
radiation-induced thyrocytes damage. |
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Keywords: | : Gamma radiation thyrocytes melatonin pinealectomy radioprotectant free radicals |
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