盐酸丁咯地尔治疗糖尿病周围神经病变 40例分析

目的 观察盐酸丁咯地尔注射液治疗糖尿病周围神经病变( ) DPN 的疗效。方法 将 80例 DPN 患者随机分成 2组,各 40例,对照组采用 DPN 的常规治疗方法,治疗组在对照组用药基础上加用盐酸丁咯地尔注射液治疗,每日静滴 150m g,用药 4周。结果 治疗 4周后,盐酸丁咯地尔治疗组对改善 DPN 患者的肢体疼痛、麻木、感觉异常等临床症状的总有效率为 79.2%,较对照组 53.3%有非常显著性差异(P <0.01) ,对神经传导速度的改善率 65.0%,较对照组 40.0%有非常显著性差异 (P <0.01) 。无明显不良反应。结论 盐酸丁咯地尔注射液对改善 DPN 患者的临床症状有明显疗效,且可以改善神经传导速度, 是有效的 DPN 治疗药物。

Effect of buflomedil hydrochloride injection on treatment of 40 cases with diabetic peripheral neuropathy

Objective To evaluate the therapeutic effect of buflomedil hydrochloride injection on 40 cases with diabetic peripheral neuropathy(DPN).Methods 80 patients with DPN were randomly divided into two groups: control group (40 cases) and treatment group (40 cases). The patients in control group were treated by routine therapy. The patients in treatment group, on the base of routine therapy, were treated with bufloomedil hydrochloride injection. All patients in two groups were treated for 4 weeks. Results The total effective rate improvement of clinical symptoms in treatment group (79.2% ) was higher than that in control group (5.33% ,P<0.01) .The improvement of nerve conduction velocity (NCV) in treatment group (65.0% ) was better than that in control group (40.0% , P<0.01). Conclusion Buflomedial hydrohloride injection is valuable in the improvement of clinical symptoms and nerve condution velocity in patients with diabetic peripheral neuropathy.