首页 | 本学科首页   官方微博 | 高级检索  
     


In vitro enhancement of the proliferative response of human T cells to autologous non-T cells by hydralazine
Authors:D Pende  F Indiveri  I Pierri  D Criscuolo  S Ferrone
Affiliation:1. Cattedra Di Clinica Medica and Immunologia Clinica, Medical School, Genoa, Italy;1. Department of Microbiology and Immunology, New York Medical College, Basic Sciences Building, Valhalla, NY 10959, U.S.A.;1. Department of Pathology, Leiden University Medical Center, Leiden, Netherlands;2. Department of Pathology, University of Washington, Seattle, Washington, USA;3. Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA;4. Department of Medicine, Imperial College, London, UK;5. Department of Pathology and Cell Biology, Columbia University Medical Center, New York, New York, USA;6. Nephropathology Center, San Gerardo Hospital-Monza, Milan Bicocca University, Milan, Italy;7. Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA;8. Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA;9. Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan;10. Department of Pathology, Necker Hospital, Paris, France;11. Department of Cellular Pathology, Oxford University Hospitals, Oxford, UK;12. Department of Pathology and laboratory Medicine, Weill Cornell University Medical Center, New York, New York, USA;13. Department of Laboratory Medicine and Pathology, Mayo Clinic Rochester, Minnesota, USA;14. Department of Pathology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA;1. Suzhou Medical College of Soochow University, Suzhou, People''s Republic of China;2. Department of Pediatrics, Affiliated Hospital of Zunyi Medical University, Zun Yi, People''s Republic of China;3. Department of Pediatrics, Guizhou Children''s Hospital, Zun Yi, People''s Republic of China;4. Collaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine, Zunyi Medical University, Zunyi, People''s Republic of China;5. Department of Cardiology, Affiliated Hospital of Zunyi Medical University, Zun Yi, People''s Republic of China;1. Guang''anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China;2. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;3. China-Japan Friendship Hospital, Institute of Medical Science, Beijing 100029, China
Abstract:While high doses of hydralazine inhibit the proliferative response of T lymphocytes to mitogens and antigens, low doses (0.15 microgram/ml) selectively enhance the proliferative response of T cells to autologous non-T cells. The effect is especially pronounced on lymphocytes which express the HLA-DR4 allospecificity. These results suggest that the autologous mixed lymphocyte response with non-T cells may represent a useful in vitro model to analyse the mechanism(s) of the immunologic abnormalities induced by hydralazine.
Keywords:
本文献已被 ScienceDirect 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号