| 再生障碍性贫血患者血清IL-8、TNF-α水平的检测及其意义 |
| |
| 引用本文： | 杨桂珍,杨萍.再生障碍性贫血患者血清IL-8、TNF-α水平的检测及其意义[J].中国基层医药,2008,15(2). |
| |
| 作者姓名： | 杨桂珍 杨萍 |
| |
| 作者单位： | 1. 南阳市中心医院血液科,河南省南阳,473009
2. 郑州大学第二附属医院检验科 |
| |
| 摘 要： | 目的 探讨再生障碍性贫血(AA)患者血清IL-8、TNF-α的变化及其意义.方法 应用酶联免疫吸附试验检测45例AA患者及30名健康人血清中IL-8、TNF-α水平.结果 血清IL-8、TNF-α水平AA组及急性AA(AAA)亚组均明显高于对照组(P＜0.05),慢性AA(CAA)亚组与对照组差异无统计学意义(P＞0.05);AAA亚组明显高于CAA亚组(P＜0.05).AA组血清IL-8与TNF-α水平呈正相关(r=0.682,P＜0.05).结论 AA患者存在细胞免疫功能紊乱,IL-8和TNF-α过量分泌可能在AA特别是在AAA的发病中起一定的作用.
|
| 关 键 词： | 贫血 再生障碍性 白细胞介素-8 肿瘤坏死因子-α |
Significance and detection of levels of IL-8,TNF-α in serum of patients with aplastic anemia |
| |
| YANG Gui-zhen,YANG Ping.Significance and detection of levels of IL-8,TNF-α in serum of patients with aplastic anemia[J].Chinese Journal of Primary Medicine and Pharmacy,2008,15(2). |
| |
| Authors: | YANG Gui-zhen YANG Ping |
| |
| Abstract: | Objective To investigate the significance of levels of IL-8,TNF-α in serum of patients with aplastic anemia(AA).Methods Serum levels of IL-8 and TNF-α in 45 patients and 30 normal controls were measured by enzyme linked immunosorbent assay.Results The serum levels of IL-8,TNF-α increased significantly in AA and acute AA(AAA)group than in the control group(P＜0.05),there was no statistical significance between chronic AA(CAA)group and the control group(P＜0.05),and the levels in AAA group were much higher than in CAA group(P＜0.05).The serum level of IL-8 was positively related to TNF-αin AA group(r=0.682,P＜0.05).Conclusion There are immunological disorders in patients with AA and the overproduction of IL-8,TNF-α might be involved in the immunopathogenesis of AA,AAA. |
| |
| Keywords: | Anemia aplastic Interleukin-8 Tumor necrosis factor-α |
| 本文献已被 万方数据 等数据库收录！ |
|
