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| 石杉碱甲胶囊和片剂治疗阿尔采末病的多中心双盲研究 | |
| 引用本文： | 陈美娟,高之旭,邓红玉,刘福根,马永兴,余慧贞,黄流清,翁正.石杉碱甲胶囊和片剂治疗阿尔采末病的多中心双盲研究[J].中国新药与临床杂志,2000,19(1):10-12. |
| 作者姓名： | 陈美娟 高之旭 邓红玉 刘福根 马永兴 余慧贞 黄流清 翁正 |
| 作者单位： | 1. 上海市精神卫生中心,上海,200030 2. 华东医院,上海,200040 3. 上海第二医科大学,附属瑞金医院,上海,200025 4. 中国人民解放军第二军医大学,附属长征医院,上海,200003 5. 山东省精神卫生中心,山东,济南,250014 |
| 摘 要： | 目的：比较石杉碱甲胶囊和片剂治疗轻中度阿尔采末病（ＡＤ）的疗效和不良反应。方法：９２例ＡＤ病人随机分２组，胶囊组５５例（男性２７例，女性 ２８例，年龄 ６９ ａ ± ｓ７ ａ）；片剂组 ３７例（男性１７例，女性 ２０例，年龄 ７１ａ± ６ａ）。给石杉碱甲胶囊或片剂 ０． １５ ｍｇ，ｐｏ， ｂｉｄ × ８ ｗｋ。结果：胶囊组和片剂组总有效率分别为 ６９％， ５７％，２组比较差异无显著意义（Ｐ＞０．０５）。结论：石杉碱甲是一个安全、有效的治疗ＡＤ药物，肢囊剂型与片剂剂型疗效相似。 |
| 关 键 词： | 石杉碱甲 胶囊 片剂 阿尔采末病 双盲法 多中心研究 |
| 文章编号： | 1007-7669(2000)01-0010-03 |
Huperzine A capsules vs tablets in treatment of Alzheimer disease: multicenter studies |
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| CHEN Mei-Juan,GAO Zhi-Xu,DENG Hong-Yu,LIU Fu-Gen,MA Yong-Xing,YU Hui-Zhen,HUANG Liu-Qing,WENG Zheng.Huperzine A capsules vs tablets in treatment of Alzheimer disease: multicenter studies[J].Chinese Journal of New Drugs and Clinical Remedies,2000,19(1):10-12. | |
| Authors: | CHEN Mei-Juan GAO Zhi-Xu DENG Hong-Yu LIU Fu-Gen MA Yong-Xing YU Hui-Zhen HUANG Liu-Qing WENG Zheng |
| Abstract: | AIM: To compare the clinical efficacies and adverse reactions of huperzine A capsules and tablets in treating Alzheimer disease(AD). METHODS: Ninety-two patients with mild to moderate AD were recruited. Fifty-five patients (M 27, F 28; age 69 a ± s 7 a) were treated with huperzine A capsule, 0. 15 ｍg,ｐｏ, bid for & wｋ and 37 patients (M 17, F 20; age 71 a± 6 a) were treated with huperzine A tablet, 0. 15 mg, po, bid for ８ wｋ. RESULT: The clinical efficacy was 69% in the huperzine A capsule group and 57% in the huperzine A tablet group (P > 0. 05 ). CONCLUSION: Huperzine A capsules is similar to huperzine A tablets in treating mild to mederate AD patients. |
| Keywords: | Huperzine A capsules tablets Alzheimer disease double-blind method multicenter studies |
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